利用建模和模拟预测肥胖患者药物清除率的变化
The Simcyp Simulator improves decision-making regarding the need for clinical studies in obese subjects.
The Simcyp Simulator improves decision-making regarding the need for clinical studies in obese subjects.
Impaired hepatic or renal function can have a major impact on pharmacokinetics. There is a high risk of adverse events in patients with these conditions. Major pharmaceutical companies and drug regulatory agencies use physiologically-based pharmacokinetic (PBPK) modeling in virtual populations to investigate the impact of hepatic or renal impairment on drug exposure as a supplement to … Continued