Month: October 2015
A Distributed Delay Approach for Modeling Delayed Outcomes in Pharmacokinetics and Pharmacodynamics Studies
Comparison of Laplacian, Quasi-Random Parametric Expectation Maximization and Non-parametric Methods for Population Analysis of a Complex Dynamic System with Non-static BQL Data
Phxnlme: An R Package that Faciliates Pharmacometrics Workflow of Phoenix NLME Analyses
Certara Scientists Participate in 14 Presentations at 6th American Conference on Pharmacometrics
Diverse agenda underscores the widespread adoption of pharmacometrics throughout the drug development process PRINCETON, NJ – Oct. 02, 2015 – Certara®, the global biosimulation technology-enabled drug development company, today announced that its scientists are presenting or co-authoring 14 workshops, seminars and poster sessions at the sixth American Conference on Pharmacometrics (ACoP6). This annual International Society … Continued
CLIP: The Command-line Interface to Phoenix NLME
Development of a Multicompartment Permeability-limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs
Achieving sufficient concentrations of antituberculosis (TB) drugs in pulmonary tissue at the optimum time is still a challenge in developing therapeutic regimens for TB. A physiologically based pharmacokinetic model incorporating a multi-compartment permeability-limited lung model was developed and used to simulate plasma and pulmonary concentrations of seven drugs. Passive permeability of drugs within the lung was predicted using an in vitro-in vivo extrapolation approach. Simulated epithelial lining fluid (ELF):plasma concentration ratios showed reasonable … Continued
