Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib
This study demonstrates how a model-informed, totality-of-evidence approach was used to select the optimal clinical…
Danielle Pillsbury2026 年 4 月 2 日
Integrated PK/PD Modeling and Machine Learning to Support CNS Compound Selection
PK/PD Modeling for CNS drug development using Phoenix NLME and machine learning for better CNS…
Certara2026 年 3 月 26 日
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
This review article examines the development of radiopharmaceutical imaging agents and radioligand therapies for pediatric…
Certara2026 年 3 月 26 日
An Integrated Nonclinical and Clinical Risk Assessment of the Effects of Investigational ATRi Tuvusertib on QTc Interval in Patients With Solid Tumors
This publication highlights how pharmacometric modeling, supported by Certara, was used to inform dose selection…
Certara2026 年 3 月 25 日
Right Dose, Right Regimen: Model-Informed Strategies for Antibody–Drug Conjugates (ADCs)
Watch this on-demand webinar to learn how model-informed strategies using PopPK, PBPK, and QSP can…
Certara2026 年 3 月 25 日
Why the Most Important Phase 3 Decisions Should Be Made Before Phase 3
Learn how advanced modeling for reimbursement strategy using MBMA and QSP strengthens payer evidence and…
Certara2026 年 3 月 24 日
Population Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Analysis for Clazakizumab in Patients With End-Stage Kidney Disease Undergoing Dialysis
This study evaluated the pharmacokinetics (PK) and pharmacokinetic–pharmacodynamic (PK–PD) relationship of clazakizumab, an anti–interleukin-6 (IL-6)…
Danielle Pillsbury2026 年 3 月 24 日
Model-informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis
This article describes how a model-informed drug development (MIDD) approach was used to support the…
Certara2026 年 3 月 24 日
Regulatory horizons 2026: clinical pharmacology strategy and regulatory expectations
Learn how regulatory expectations in clinical pharmacology are evolving and how to build a strategy…
Certara2026 年 3 月 24 日
