Enhanced QSAR Models for Drug-triggered Inhibition of the Main Cardiac Ion Currents
The currently changing cardiac safety testing paradigm suggests, among other things, a shift towards using in silico models of cellular electrophysiology and assessment of a concomitant block of multiple ion channels. In this study, a set of four enhanced QSAR models have been developed: for the rapid delayed rectifying potassium current (IKr), slow de-layed rectifying … Continued
