Applied BioMath Assess™
Applied BioMath Assess™
Quantitative Systems Pharmacology (QSP) Modeling Software
- Point-and-click, QSP modeling software to assess efficacy, safety, and therapeutic index for early stage biotherapeutics.
- Simulating pre-built models across a range of therapeutic modalities and disease areas helps inform target selection, project clinical dose requirements, design a lead optimization funnel, and identify areas of program risk.
Our QSP Modeling Software Helps You Answer the Tough Questions
How hard will it be to develop the biologic (e.g., affinity, avidity, format, T1/2 dose, dose frequency, uncertainty)?
What are the pros and cons of targeting the ligand or receptor?
Should I expect Target Mediated Drug Disposition (TMDD) with this target?
Do I already have my Lead(s) or do I need to continue optimizing?
How likely is it that my dose will be too high for High Concentration Liquid Formulation?
Can my bispecific be differentiated from fixed dose combinations of monospecific antibodies?
Key Features
Gain Deeper Insight with Built-in Analyses and Interactive Plots
- Perform 1- or 2-dimensional scans by simply selecting scan parameters and output feasibility criteria including percent inhibition, activation, and target engagement.
- Visually assess results and key parameter values by interacting with dose-response and pharmacokinetic and pharmacodynamic (PK/PD) plots.
Get Started Quickly with Pre-built Pharmacology Models
Applied BioMath Assess™ offers several libraries of monospecific and bispecific, single compartment and multicompartment models covering common pharmacologies.
- Biotherapeutic 模型包
- Cell Engager 模型包
- Avidity 模型包
- 基因疗法模型包
- 蛋白质降解剂模型包
- ADC Model Pack
Easily Explore “What If” Questions with Scenarios
- Create Scenarios, or sets of parameters, to easily contrast and compare various scenarios.
- Add, duplicate, or delete scenarios with the click of a button in the Applied BioMath Assess interface.
- Vary parameters in the scenario table to explore risk and uncertainty while high-performance computing supports near real-time simulation when any scenario is selected.
Document, Share, and Reproduce Your Analyses
- Save scenario sets for traceability and reproducibility and/or to share work with your colleagues.
- Automatically generate a PDF report with a unique ID and date and time stamp and download plots individually as PNG images.
See Our QSP Modeling Software in Action
Applied BioMath Assess™ can quickly help determine feasibility of a project.
Model Libraries
Applied BioMath Assess™ offers several libraries of monospecific and bispecific, single compartment and multicompartment models covering common pharmacologies.
Applied BioMath Assess™ includes 18 models covering 9 common pharmacologies. Each pharmacology has a one-compartment model version and a four-compartment model version with monospecific and bispecific antibodies.
Models for solid tumors, in-vitro experiments, and solid tumors with 2 cell types.
Includes 4 models covering in vivo and in vitro models of PROTAC and Molecular Glue Degrader pharmacologies.
An advanced biotherapeutic model pack that incorporates avid bivalent antibodies into many of the core biotherapeutic models.
Models covering 8 LNP-encapsulated mRNA and siRNA therapies.
Includes 42 models covering monospecific and bispecific ADCs with and without avidity.
客户对我们的评价
Schedule a live demo of Applied BioMath Assess™ or request a free trial
Complete the form to book your no-obligation demo or try Applied BioMath Assess™ QSP Modeling Software for free and see how better off you could be!
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On-Demand Support
Have any questions about Applied BioMath Assess or interested in seeing a demo? We have software engineers ready to chat!
Contact us today at abm-support@certara.com.
Documentation
Visit our Applied BioMath Assess documentation portal for product documentation as well as video case studies.
