Publication

A study to explore the appropriateness of dosing regimen of vancomycin in critically ill patients in a tertiary care unit of India

Learn how weight and creatinine clearance improve prediction; standard dosing insufficient using Phoenix NLME.

Certara2022 年 6 月 30 日

刊物

Evaluation of Pharmacokinetic Interactions Between the New SGLT2 Inhibitor SHR3824 and Valsartan in Healthy Chinese Volunteers.

Find out how co‑administration shows BE‑range PK for both drugs using Phoenix WinNonlin.

Certara2022 年 6 月 28 日

Case Study

Simcyp Simulator 有助于优化成人和青少年孤儿病患者的用药剂量

全世界约有 400,000 名先天性肾上腺增生症（CAH）患者。Current therapy for CAH uses a…

Certara2022 年 6 月 6 日

刊物

A randomized, cross-over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence.

Explore how brand and generics show similar exposure but different absorption timing using Phoenix NLME.

Certara2022 年 5 月 21 日

Publication

Comparative clinical study of the pharmacokinetics and bioequivalence of the combined drug Mioreol and the combined use of mono-drugs containing donepezil and memantine

Discover how linear PK up to 600 mg; saturation at 800 mg; PK modelled using…

Certara2022 年 5 月 13 日

Publication

Population PK of polymyxin B in critically ill patients receiving continuous venovenous haemofiltration

See how CVVH reduces AUC three‑fold; simulations support 200 mg load + 150 mg q12h…

Certara2022 年 5 月 5 日

Publication

Population Pharmacokinetics of Oral-Based Administration of Cannabidiol in Healthy Adults: Implications for Drug Development

See how uncovered large inter‑individual variability in CBD pharmacokinetics, showing 3.6‑fold exposure differences and long…

Certara2022 年 4 月 19 日

Publication

Pharmacokinetics and Safety of Ferric Pyrophosphate Citrate in Chinese Subjects with and without Hemodialysis-Dependent Stage 5 Chronic Kidney Disease

Discover how evaluated ferric pyrophosphate citrate pharmacokinetics and safety in healthy and hemodialysis‑dependent CKD patients…

Certara2022 年 4 月 5 日

Publication

Population Pharmacokinetic (Pop-PK) Analysis of Torsemide in Healthy Korean Males Considering CYP2C9 and OATP1B1 Genetic Polymorphisms

Explore how CYP2C9 and OATP1B1 genetic effects on torsemide PK in healthy Korean males, supporting…

Certara2022 年 4 月 1 日

Publication

Co-Administration with Voriconazole Doubles the Exposure of Ruxolitinib in Patients with Hematological Malignancies

Find out how voriconazole more than doubles ruxolitinib exposure, supporting dose adjustment guidance for hematologic…

Certara2022 年 3 月 25 日

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建模与模拟

A study to explore the appropriateness of dosing regimen of vancomycin in critically ill patients in a tertiary care unit of India

Evaluation of Pharmacokinetic Interactions Between the New SGLT2 Inhibitor SHR3824 and Valsartan in Healthy Chinese Volunteers.

Simcyp Simulator 有助于优化成人和青少年孤儿病患者的用药剂量

A randomized, cross-over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence.

Comparative clinical study of the pharmacokinetics and bioequivalence of the combined drug Mioreol and the combined use of mono-drugs containing donepezil and memantine

Population PK of polymyxin B in critically ill patients receiving continuous venovenous haemofiltration

Population Pharmacokinetics of Oral-Based Administration of Cannabidiol in Healthy Adults: Implications for Drug Development

Pharmacokinetics and Safety of Ferric Pyrophosphate Citrate in Chinese Subjects with and without Hemodialysis-Dependent Stage 5 Chronic Kidney Disease

Population Pharmacokinetic (Pop-PK) Analysis of Torsemide in Healthy Korean Males Considering CYP2C9 and OATP1B1 Genetic Polymorphisms

Co-Administration with Voriconazole Doubles the Exposure of Ruxolitinib in Patients with Hematological Malignancies

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