Publication

Population pharmacokinetics and limited sampling strategies of polymyxin B in critically ill patients

Learn how PopPK modelling supports limited sampling strategies and individualized polymyxin B dosing using Phoenix…

Certara2023 年 3 月 2 日

Publication

Simultaneous pharmacokinetic assessment of phytopharmaceuticals in fenugreek extract using LC-MS/MS in Sprague-Dawley rats

Simultaneous PK profiling of four fenugreek phytochemicals in rats, supporting development of fenugreek‑based formulations by…

Certara2023 年 2 月 27 日

Case Study

Using Modeling & Simulation to Develop a Dosing Regimen for a Bispecific Antibody for Pediatric Cancer

Bispecific antibodies are an emerging class of antibodies developed in recent years that provide new…

Certara2023 年 1 月 23 日

Publication

Population pharmacokinetic analysis of TQ-B3203 following intravenous administration of TQ-B3203 liposome injection in Chinese patients with advanced solid tumors

See how PopPK modelling shows bilirubin, BMI, and lean body weight meaningfully affect TQ‑B3203 clearance…

Certara2023 年 1 月 16 日

Publication

Pharmacokinetics and Bioequivalence of the Lubiprostone Capsule in Healthy Chinese Subject

Learn how dose‑proportional PK and fed‑state bioequivalence confirmed for lubiprostone using Phoenix WinNonlin.

Certara2023 年 1 月 10 日

Publication

Population pharmacokinetics and limited sampling strategy for therapeutic drug monitoring of mycophenolate mofetil in Japanese patients with lupus nephritis

Find out how renal function and albumin drive MPA clearance; 1–4 h sampling best predicts…

Certara2023 年 1 月 9 日

Publication

Population Pharmacokinetics and Dosing Regimen Optimization of Linezolid in Cerebrospinal Fluid and Plasma of Post-operative Neurosurgical Patients

Explore how highly variable CSF penetration; PopPK modelling supports renal‑ and inflammation‑adjusted dosing using Phoenix…

Certara2022 年 12 月 22 日

Publication

Establishment of PK-PD model in anti-inflammatory active components in Inula cappa extract based on lipopolysaccharide-induced in vitro inflammation model

Discover how PK‑PD modelling shows anti‑inflammatory components reduce NO and TNF‑α in inflamed cells using…

Certara2022 年 12 月 1 日

Publication

Pharmacokinetics and pharmacodynamics of polymyxin B and proposed dosing regimens in elderly patients with multi-drug-resistant Gram-negative bacterial infections

See how fixed 50–75 mg dosing meets PK/PD targets; albumin has minor PK impact using…

Certara2022 年 11 月 11 日

Publication

Pharmacokinetic and Bioequivalent Study of Potassium Chloride Sustained-Release Tablet Under Different Dietary Conditions in Healthy Chinese Subjects

Learn how urinary potassium excretion comparable across formulations and diets; BE confirmed using Phoenix WinNonlin.

Certara2022 年 11 月 2 日

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Population pharmacokinetics and limited sampling strategies of polymyxin B in critically ill patients

Simultaneous pharmacokinetic assessment of phytopharmaceuticals in fenugreek extract using LC-MS/MS in Sprague-Dawley rats

Using Modeling & Simulation to Develop a Dosing Regimen for a Bispecific Antibody for Pediatric Cancer

Population pharmacokinetic analysis of TQ-B3203 following intravenous administration of TQ-B3203 liposome injection in Chinese patients with advanced solid tumors

Pharmacokinetics and Bioequivalence of the Lubiprostone Capsule in Healthy Chinese Subject

Population pharmacokinetics and limited sampling strategy for therapeutic drug monitoring of mycophenolate mofetil in Japanese patients with lupus nephritis

Population Pharmacokinetics and Dosing Regimen Optimization of Linezolid in Cerebrospinal Fluid and Plasma of Post-operative Neurosurgical Patients

Establishment of PK-PD model in anti-inflammatory active components in Inula cappa extract based on lipopolysaccharide-induced in vitro inflammation model

Pharmacokinetics and pharmacodynamics of polymyxin B and proposed dosing regimens in elderly patients with multi-drug-resistant Gram-negative bacterial infections

Pharmacokinetic and Bioequivalent Study of Potassium Chloride Sustained-Release Tablet Under Different Dietary Conditions in Healthy Chinese Subjects

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