Comparative pharmacokinetics and tissue distribution of primaquine enantiomers in mice
See how major PK and metabolic differences between primaquine enantiomers, informing safer and more effective…
Certara2022 年 2 月 5 日
Bioequivalence and Safety Assessment of Two Formulations of Metformin Hydrochloride Sustained-Release Tablets (Yuantang® SR and Glucophage® XR) Under Fed Conditions in Healthy Chinese Adult Subjects: An Open-Label, Two-Way Crossover, Sequence Randomized Phase I Clinical Trial
Learn how the confirmed bioequivalence of metformin SR formulations under fed conditions, with matched PK…
Certara2022 年 1 月 21 日
The effect of nutritional status on the pharmacokinetic profile of acetaminophen+A124:N124
Explore how nutritional status strongly alters acetaminophen PK at toxic doses, with low‑protein diets producing…
Certara2022 年 1 月 20 日
Application of Population Pharmacokinetic Analysis to Characterize CYP2C19 Mediated Metabolic Mechanism of Voriconazole and Support Dose Optimization
Discover how major CYP2C19 genotype effects on voriconazole PK, supporting genotype‑guided dose adjustments to avoid…
Certara2022 年 1 月 3 日
The impact of rifampicin on the pharmacokinetics of fuzuloparib in healthy Chinese male volunteers
See how rifampicin reduces fuzuloparib exposure by up to 90%, confirming a major CYP3A4 induction…
Certara2021 年 12 月 26 日
Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low-grade glioma
Find out how lower vinorelbine exposure in children and strong BSA effects, supporting dose refinement…
Certara2021 年 12 月 13 日
Population Pharmacokinetics of Polymyxin B in Obese Patients for Resistant Gram-Negative Infections
Learn how adjusted‑body‑weight dosing optimises polymyxin B exposure in obese patients, avoiding toxicity while achieving…
Certara2021 年 11 月 22 日
A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats
Explore how altered PK of fenugreek bioactives in diabetic rats, with faster absorption and slower…
Certara2021 年 11 月 16 日
Pharmacokinetics and Bioequivalence of a Generic and a Branded Budesonide Nasal Spray in Healthy Chinese Subjects
Discover how bioequivalence of generic and branded budesonide nasal sprays, with matched PK and strong…
Certara2021 年 11 月 16 日
