Further to the work with the Simcyp Consortium, the Certara Simcyp team collaborates with other organizations and funds research to develop unique modules. While connected to the Simcyp PBPK Simulator, these modules require additional licensing.
Simcyp™ specialized modules
Simcyp 扩展模块
Simcyp 动物模拟器
Simcyp Animal is a PBPK modeling platform for rat, dog, mouse and monkey, used to explain drug behavior that would be difficult to obtain via in vivo experimentation.
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Simcyp™ Pediatric
Simcyp Pediatric is the industry’s most sophisticated technology for modeling drug performance and determining dosing in neonates, infants, and children. Simulator 包含大量关于人口统计学、发育生理学和药物消除途径发生的资料库。
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Cardiac Safety Simulator (CSS)
CSS is a systems biology-driven modeling and simulation-based platform for the assessment of the pro-arrhythmic potency of drugs, new chemical entities, and other xenobiotics within the targeted clinical population. 它能够对心脏易感性进行早期评估，并用于心脏风险的临床前和临床评估。
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Simcyp Long Acting Injectable (LAI)
LAI drug delivery provides advantages for specific drugs and patient types, including reduced toxicity, reduced dosing frequency and enhanced compliance. Simcyp 的 LAI 模块用于设计实验、缩小有希望的候选制剂范围、确定动物研究或临床试验并根据研究细节微调制剂。
Simcyp Lactation
Dosing information for pregnant and lactating women is generally not available on the drug label. Simcyp is focused on this topic, looking at women’s health across the gestational cycle. The Simcyp lactation module predicts drug exposure in the mother and the milk to be given to the child, allowing for proper dosing of this fragile population.
虚拟生物等效性
The Virtual Bioequivalence (VBE) module facilitates running a range of common BE studies incorporating within and between subjects variability and batch to batch formulation changes. 它还允许进行 BE 统计分析、评估虚拟 BE 研究的能力，并确定临床相关的溶出安全空间。
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Simcyp 生物制剂
The Simcyp PBPK Simulator has been expanded, enhanced, tested and applied to biologics drugs. Simcyp Biologics enables scientists to model many different biologics modalities, including monoclonal antibodies, protein conjugates, Fc-fusion proteins, bispecifics, and other proteins and peptides.
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Simcyp applications
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Maximize your drug development journey with our specialized modules for the Simcyp PBPK Simulator. From predicting pediatric dosing to evaluating cardiac safety and bioavailability, Certara Simcyp offers tailored PBPK modeling solutions to meet your unique challenges. Connect with our experts to integrate advanced simulations into your pipeline and drive smarter, faster decision-making.
Address diverse populations with precise PBPK modeling.
Enhance decision-making across preclinical and clinical phases.
Confidently navigate complex regulatory landscapes.
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