Development of CYP2D6 and CYP3A4 in the First Year of Life
Recently, Blake et al . ‘‘Ontogeny of dextromethorphan O- and N-demethylation in the first year…
Certara2008 年 5 月 1 日
CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene
Clomiphene is a first line treatment for anovulation, a common cause of infertility. Response to…
Certara2008 年 4 月 30 日
Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems
Recombinantly expressed CYP450 systems (rCYPs) are often used to screen for irreversible/quasi-irreversible enzyme inhibitors during…
Certara2007 年 9 月 1 日
The Problems in Scaling Adult Drug Doses to Children
Many drugs are unlicensed in children and consequently their doses have been scaled down from…
Certara2007 年 3 月 15 日
Predictive Population Pharmacokinetic/Pharmacodynamic Model for a Novel COX-2 Inhibitor
The objectives of these analyses were to (1) develop a population pharmacokinetic/pharmacodynamic model for a…
Certara2007 年 3 月 1 日
Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA
The aim of this study was to model the in vivo kinetic consequences of mechanism-based…
Certara2006 年 11 月 1 日
Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates
Prediction of the exposure of neonates, infants and children to xenobiotics is likely to be…
Certara2006 年 9 月 1 日
Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor
A predictive population pharmacokinetic model was developed for a novel cyclooxygenase-2 (COX-2) inhibitor CS-706, using…
Certara2006 年 5 月 1 日
Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation
The aim of this study was to develop a pain relief model for a cyclooxygenase…
Certara2006 年 4 月 1 日
Changes in Liver Volume from Birth to Adulthood: A Meta-analysis
A diversity of equations is available for the estimation of liver volume (LV), derived from…
Certara2005 年 12 月 1 日
