Model-based Development of Gemcabene, a New Lipid-altering Agent
The purpose of this study was to evaluate the value of model-based, quantitative decision making…
Certara2005 年 10 月 7 日
Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model
Ciclesonide is a novel and effective inhaled corticosteroid for the treatment of asthma that is…
Certara2005 年 9 月 1 日
Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation
A novel model-based meta-analysis was used to quantify the dose-response relationship of sumatriptan and eletriptan…
Certara2005 年 9 月 1 日
Modelling Approaches to Dose Estimation in Children
Most of the drugs on the market are originally developed for adults and dosage selection…
Certara2005 年 6 月 1 日
Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients
Olmesartan medoxomil (CS-866) is a new orally active angiotensin II receptor antagonist that is highly…
Certara2005 年 1 月 1 日
The Use of Clinical Trial Simulation to Support Dose Selection: Application to Development of a New Treatment for Chronic Neuropathic Pain
Pregabalin is being evaluated for the treatment of neuropathic pain. Two phase 2 studies were…
Certara2003 年 11 月 1 日
Pharmacokinetics of Melagatran and the Effect on Ex Vivo Coagulation Time in Orthopedic Surgery Patients Receiving Subcutaneous Melagatran and Oral Ximelagatran: A Population Model Analysis
Ximelagatran, an oral direct thrombin inhibitor, is rapidly bioconverted to melagatran, its active form. The…
Certara2003 年 1 月 1 日
