Mechanism-based Inhibition of Cytochrome P450 Enzymes: An Evaluation of Early Decision-making In Vitro Approaches and Drug-drug Interaction Prediction Methods Publication Mechanism-based Inhibition of Cytochrome P450 Enzymes: An Evaluation of Early Decision-making In Vitro Approaches and Drug-drug Interaction Prediction Methods The ability to use in vitro human cytochrome P450 (CYP) time-dependent inhibition (TDI) data for in vivo drug-drug interaction (DDI) predictions should be viewed as…Danielle Pillsbury2009 年 2 月 15 日
The Simcyp Population-based ADME Simulator Publication The Simcyp Population-based ADME Simulator The Simcyp® population-based absorption, distribution, metabolism and excretion simulator is a platform and database for…Danielle Pillsbury2009 年 2 月 6 日
Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients Publication Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients What is already known about this subject The use of intravenous pantoprazole, a proton pump…Danielle Pillsbury2009 年 2 月 1 日
Metabolism of Dextrorphan by CYP2D6 in Different Recombinantly Expressed Systems and Its Implications for the In Vitro Assessment of Dextromethorphan Metabolism Publication Metabolism of Dextrorphan by CYP2D6 in Different Recombinantly Expressed Systems and Its Implications for the In Vitro Assessment of Dextromethorphan Metabolism Cytochrome P450 2D6 (CYP2D6) mediated formation of dextrorphan (DOR) from dextromethorphan (DEX) is widely used…Danielle Pillsbury2009 年 2 月 1 日
Covariation of Human Microsomal Protein per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling Publication Covariation of Human Microsomal Protein per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling Scaling of metabolic clearance values from liver microsomal data or recombinantly expressed cytochrome P450 enzymes…Danielle Pillsbury2008 年 12 月 1 日
Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential Publication Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential AIMS: To characterize the cytochrome P450 enzyme(s) responsible for the N-dealkylation of maraviroc in vitro,…Danielle Pillsbury2008 年 10 月 1 日
Integrating Systems Approaches into Pharmaceutical Sciences Publication Integrating Systems Approaches into Pharmaceutical Sciences During the first week of December 2007, the European Federation for Pharmaceutical Sciences (EUFEPS) and…Danielle Pillsbury2008 年 9 月 2 日
Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability Publication Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability This is a summary report of the EUFEPS & COST B25 conference on Bioavailability and…Danielle Pillsbury2008 年 8 月 1 日
Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain Publication Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain The aim of this study was to develop a pain relief model for a cyclooxygenase…Danielle Pillsbury2008 年 7 月 1 日
In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and Their Utility for Predicting Drug-drug Interactions Publication In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and Their Utility for Predicting Drug-drug Interactions It is widely accepted that today's practice of polypharmacy inevitably increases the incidence of drug-drug…Danielle Pillsbury2008 年 6 月 1 日