Publication

Influence of Route of Administration and Liposomal Encapsulation on Blood and Lymph Node Exposure to the Protein VEGF-C156S

VEGF-C156S is a recombinant form of human vascular endothelial growth factor C (VEGF-C), which targets…

Certara2012 年 2 月 1 日

Publication

Effect of Ketoconazole on the Pharmacokinetics of Axitinib in Healthy Volunteers

Axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptors 1,…

Certara2012 年 2 月 1 日

Publication

Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression

Objective: Taspine, isolated from Radix et Rhizoma Leonticis has demosntrated potential proctiective effects against cancer.…

Certara2012 年 1 月 1 日

Publication

Preliminary Comparison of Sertraline Levels in Postbariatric Surgery Patients Versus Matched Non-surgical Cohort

Roux-en-Y gastric bypass (RYGB) is the most frequent bariatric procedure performed in the United States,…

Certara2012 年 1 月 1 日

Publication

Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite

Clopidogrel is an antiplatelet agent widely used in cardiovascular diseases and an inactive prodrug that…

Certara2012 年 1 月 1 日

Publication

Application of PBPK Modeling in Drug Discovery and Development at Pfizer

Early prediction of human pharmacokinetics (PK) and drug-drug interactions (DDI) in drug discovery and development…

Certara2012 年 1 月 1 日

Publication

γ-hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters

The drug of abuse γ-hydroxybutyrate (GHB) displays nonlinear renal clearance, which has been attributed to…

Certara2012 年 1 月 1 日

Publication

ST Analysis of the Fetal Electrocardiogram in Intrapartum Fetal Monitoring: A Meta-analysis

The objective of this study was to compare the effects of ST-waveform analysis in combination…

Certara2012 年 1 月 1 日

Publication

Exposure-response Relationship of AMG 386 in Combination with Weekly Paclitaxel in Recurrent Ovarian Cancer and Its Implication for Dose Selection

The purpose of this study was to characterize exposure–response relationships of AMG 386 in a…

Certara2012 年 1 月 1 日

Publication

Pre-clinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics

The preclinical absorption, distribution, metabolism, and excretion (ADME) properties of Pracinostat -1H-benzimidazol-5-yl]-N-hydroxyarylamide hydrochloride; SB939], an…

Certara2011 年 12 月 1 日

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Influence of Route of Administration and Liposomal Encapsulation on Blood and Lymph Node Exposure to the Protein VEGF-C156S

Effect of Ketoconazole on the Pharmacokinetics of Axitinib in Healthy Volunteers

Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression

Preliminary Comparison of Sertraline Levels in Postbariatric Surgery Patients Versus Matched Non-surgical Cohort

Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite

Application of PBPK Modeling in Drug Discovery and Development at Pfizer

γ-hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters

ST Analysis of the Fetal Electrocardiogram in Intrapartum Fetal Monitoring: A Meta-analysis

Exposure-response Relationship of AMG 386 in Combination with Weekly Paclitaxel in Recurrent Ovarian Cancer and Its Implication for Dose Selection

Pre-clinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics

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