Publication: Clinical Pharmacology & Therapeutics: Volume 117, Issue 2
概述
庞贝病是一种复杂罕见病，分为严重的婴儿型（IOPD）和晚发型（LOPD）。To better understand treatment efficacy for IOPD patients, Sanofi’s team developed a quantitative systems pharmacology (QSP) Virtual Twin® model, leveraging Certara’s Virtual Twin technology, to compare the effects of avalglucosidase alfa vs. the current standard of care.
Author(s): Chanchala Kaddi, Mengdi Tao, Silke Bergeler, Kelly George, Hugo Geerts, Piet H. van der Graaf, Julie L. Batista, Meredith Foster, Catherine Ortemann-Renon, Atef Zaher, Kristina An Haack, Susana Zaph
Year: 2024 年 12 月 4 日
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