Publication: Journal of Clinical Pharmacy and Therapeutics
Abstract
This review examines how model-informed precision dosing (MIPD) is advancing pediatric antimicrobial therapy by combining population pharmacokinetic (PopPK) models with patient-specific data to optimize dosing. The authors discuss the limitations of traditional therapeutic drug monitoring (TDM), the growing role of Bayesian forecasting and clinical decision support tools, and the challenges to broader clinical adoption. The article highlights how MIPD can improve therapeutic outcomes while reducing toxicity and supports wider implementation of model-informed approaches in pediatric precision medicine.
Authors: S. Y. Amy Cheung (Certara), Jing Kai Lam, Xiaoyan Yang, Baharudin Ibrahim, Amirrudin Kamsin, Jinxin Zhao, Xiaofen Liu, Jamaludin Elis, Nusaibah Abdul Rahim, Yu-Wei Lin
Published: 2026 年 7 月 22 日
Optimize Precision Dosing with Population PK Modeling
Discover how Certara helps sponsors and healthcare organizations apply population PK modeling, Bayesian forecasting, and model-informed drug development (MIDD) strategies to optimize dosing decisions across the drug development lifecycle.
