蛋白质降解剂模型包
蛋白质降解剂模型包
What’s Included?
Applied BioMath Assess™ Protein Degrader Model Pack includes 4 models covering in vivo and in vitro models of PROTAC and Molecular Glue Degrader pharmacologies.
- PROTAC degrading an intracellular protein in vitro (beta)
- An in vitro model of a PROTAC targeting and degrading intracellular proteins
- MGD degrading an intracellular protein in vitro (beta)
- An in vitro model of a molecular glue degrader targeting and degrading intracellular proteins
- PROTAC degrading an intracellular protein in vivo (beta)
- An in vivo model of a PROTAC targeting and degrading intracellular proteins
- MGD degrading an intracellular protein in vivo (beta)
- An in vivo model of a molecular glue degrader targeting and degrading intracellular proteins
Insights on Molecular Glue Degraders
Hear from Josh Apgar, PhD, VP, QSP Software and Products at Certara as he discusses how modeling approaches can help address the challenges of molecular glue drug development.
Model Resources
Each model in the Protein Degrader Pack includes a pharmacology diagram (Figure 1) with model parameters and their nominal values (Figure 2).
Figure 1: Model Diagrams
Figure 2: Model Parameters
Each model in Applied BioMath Assess™ Protein Degrader Model Pack has a unique set of parameters, a sample of which is shown here, based on the model pharmacology and number of compartments. More details on the full list of parameters are available upon request. In the app, each parameter contains a default value based on expansive literature searches and references.
网络研讨会
引导分子胶降解剂（Molecular Glue Degrader）的目标和先导优化
Additional Model Packs
18 models covering 9 common pharmacologies.
Models for solid tumors, in-vitro experiments, and solid tumors with 2 cell types.
8 models covering LNP-encapsulated mRNA and siRNA therapies
Models covering both soluble and membrane ligand pharmacologies.
Includes 42 models covering monospecific and bispecific ADCs with and without avidity.
蛋白质降解剂模型包
Complete the form to receive your copy of the Protein Degrader Model Pack overview.
支持
On-Demand Support
Have any questions about Applied BioMath Assess or interested in seeing a demo? We have software engineers ready to chat!
Contact us today at abm-support@certara.com.
Documentation
Visit our Applied BioMath Assess documentation portal for product documentation as well as video case studies.
