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How LC-MS Proteomics Is Revolutionizing PBPK Modeling and Simulation

Drug-metabolizing enzymes and drug transporters play an important role in hepatic drug metabolism and disposition…

Certara2016 年 2 月 18 日

Blog

建模与模拟如何为患者带来新型的免疫肿瘤疗法

Immuno-oncology, which harnesses the patient's own immune system to fight cancer, is one of the…

Certara2016 年 2 月 16 日

博客

Conventional & Mechanistic IVIVC: Complementary or Clashing Methods?

An IVIVC (in vitro-in vivo correlation) is a mathematical relationship that predicts key pharmacokinetic parameters…

Certara2016 年 2 月 9 日

Publication

Impact of Carprofen Administration on Stress and Nociception Responses of Calves to Cautery Dehorning

The objective of this study was to investigate the effects of carprofen administered immediately before…

Certara2016 年 2 月 1 日

Publication

Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases

Certara2016 年 2 月 1 日

Publication

Incorporating In Vitro Information on Drug Metabolism into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphisms on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application

In vitro-in vivo extrapolation of clearance, embedded in a clinical trial simulation, was used to…

Certara2016 年 2 月 1 日

Publication

Short Communication Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are Associated with p16 INK4a Expression in Subjects on Combination Therapy

Certara2016 年 1 月 5 日

Publication

Hot Topic: Early Postpartum Treatment of Commercial Dairy Cows with Nonsteroidal Antiinflammatory Drugs Increases Whole-lactation Milk Yield

Previous research has shown that postpartum administration of the nonsteroidal antiinflammatory drug (NSAID) sodium salicylate…

Certara2016 年 1 月 1 日

Publication

Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis

Mastitis is a frequent problem among dairy cows, reducing milk yield and increasing cull rates.…

Certara2016 年 1 月 1 日

Publication

A Bottom-up Whole-body Physiologically-based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins

Certara2016 年 1 月 1 日

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pre-update

How LC-MS Proteomics Is Revolutionizing PBPK Modeling and Simulation

建模与模拟如何为患者带来新型的免疫肿瘤疗法

Conventional & Mechanistic IVIVC: Complementary or Clashing Methods?

Impact of Carprofen Administration on Stress and Nociception Responses of Calves to Cautery Dehorning

Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases

Incorporating In Vitro Information on Drug Metabolism into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphisms on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application

Short Communication Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are Associated with p16 INK4a Expression in Subjects on Combination Therapy

Hot Topic: Early Postpartum Treatment of Commercial Dairy Cows with Nonsteroidal Antiinflammatory Drugs Increases Whole-lactation Milk Yield

Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis

A Bottom-up Whole-body Physiologically-based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins

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