Publication

Development of a Multicompartment Permeability-limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs

Achieving sufficient concentrations of antituberculosis (TB) drugs in pulmonary tissue at the optimum time is still a challenge in…

Certara2015 年 10 月 1 日

Blog

How to Optimize Your Drug Label Using Modeling and Simulation Technology

As a trained pharmacist and scientist, I think a lot about patient care and how…

Certara2015 年 9 月 29 日

Knowledge Base

9 Things Your Boss Wishes You Knew About PK/PD Modeling

Over the course of my career, I have taught the theory and practical applications of PK/PD…

Certara2015 年 9 月 15 日

Publication

Modeling & Simulation Relating Survival to Tumor Growth Inhibition in Patients

The published OS model and resultant simulations can be leveraged to support Phase II design…

Certara2015 年 9 月 1 日

Publication

Are Physiologically-based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site

Physiologically based pharmacokinetic (PBPK) models can over-predict maximum plasma concentrations (Cmax) following intravenous administration. A proposed explanation is that invariably…

Certara2015 年 9 月 1 日

Knowledge Base

Derivation for Logarithmic Trapezoidal AUC Calculation

Calculating area under the curve requires the use of two separate equations: one is follows…

Certara2015 年 8 月 5 日

Blog

有助于您理解 PBPK 建模和模拟的 100 篇文章

As a company with a strong academic foundation, our scientists actively publish the results of…

Certara2015 年 7 月 28 日

Publication

Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium Tuberculosis

Certara2015 年 7 月 23 日

Publication

Population Pharmacokinetic Modeling of Motesanib and Its Active Metabolite, M4, in Cancer Patients

Motesanib is a small molecule and potent multikinase inhibitor with antiangiogenic and antitumor activity. Population…

Certara2015 年 7 月 23 日

Blog

How to Revamp Your Approach to Conventional IVIVC Models

An IVIVC (in vitro-in vivo correlation) is a predictive mathematical model describing the relationship between…

Certara2015 年 7 月 21 日

pre-update

Development of a Multicompartment Permeability-limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs

How to Optimize Your Drug Label Using Modeling and Simulation Technology

9 Things Your Boss Wishes You Knew About PK/PD Modeling

Modeling & Simulation Relating Survival to Tumor Growth Inhibition in Patients

Are Physiologically-based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site

Derivation for Logarithmic Trapezoidal AUC Calculation

有助于您理解 PBPK 建模和模拟的 100 篇文章

Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium Tuberculosis

Population Pharmacokinetic Modeling of Motesanib and Its Active Metabolite, M4, in Cancer Patients

How to Revamp Your Approach to Conventional IVIVC Models

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