Pharmacokinetics of Melagatran and the Effect on Ex Vivo Coagulation Time in Orthopedic Surgery Patients Receiving Subcutaneous Melagatran and Oral Ximelagatran: A Population Model Analysis Publication Pharmacokinetics of Melagatran and the Effect on Ex Vivo Coagulation Time in Orthopedic Surgery Patients Receiving Subcutaneous Melagatran and Oral Ximelagatran: A Population Model Analysis Ximelagatran, an oral direct thrombin inhibitor, is rapidly bioconverted to melagatran, its active form. The…Certara2003 年 1 月 1 日
Combining Drug-disease and Economic Modeling to Inform Drug Development Decisions Publication Combining Drug-disease and Economic Modeling to Inform Drug Development Decisions Drug-disease models and clinical trial simulations are increasingly being used to support trial design and…Certara2001 年 11 月 1 日
A Population Pharmacokinetic/Pharmacodynamic Analysis of Repeated Measures Time-to-event Pharmacodynamic Responses: The Antiemetic Effect of Ondansetron Publication A Population Pharmacokinetic/Pharmacodynamic Analysis of Repeated Measures Time-to-event Pharmacodynamic Responses: The Antiemetic Effect of Ondansetron This paper presents and illustrates methodology for specifying, estimating, and evaluating a predictive model for…Certara1999 年 12 月 1 日