Modeling effective doses of therapeutic antibodies targeting clustered surface receptors
Discover how semi-mechanistic PK/receptor-occupancy modeling reveals that lower, subcutaneous doses, not maximum tolerated doses, optimize…
Danielle Pillsbury2026 年 9 月 23 日
Model-Informed Strategies for ADC Development
Explore how model informed drug development can help ADC developers optimize dosing, reduce uncertainty, strengthen…
Danielle Pillsbury2026 年 9 月 22 日
Semi-Mechanistic Joint Population Pharmacokinetic Modeling of the Novel Antituberculosis Drug Sorfequiline and Its Metabolite M3 in Healthy Volunteers
A semi-mechanistic population PK model characterizes sorfequiline and its active M3 metabolite to support DDI…
Certara2026 年 9 月 18 日
Pharmacometric Analysis of Givinostat to Support Individualized Dosing Recommendations in Pediatric Patients with Duchenne Muscular Dystrophy
Pharmacometric modeling of givinostat in pediatric DMD supported a simplified 4-band weight-based dosing regimen without…
Certara2026 年 9 月 14 日
Beyond Simple Allometric Scaling: Why Time-Course Methods Win for First-in-Human Predictions
Simple allometric scaling stops at clearance and volume. See how Dedrick plots and the Wajima…
Danielle Pillsbury2026 年 9 月 11 日
From PK Data to Document: An AI-Driven Daytrip with Phoenix Cloud
Go from raw PK data to a submission-ready deliverable in a day. See AI-assisted non-compartmental…
Arjen Bos2026 年 9 月 3 日
From Sentence to Simulation: Bringing AI Assistance to Pharmacometrics Modeling
Describe pharmacometric models in natural language and let AI write ready-to-run NLME code. See the…
Arjen Bos2026 年 9 月 1 日
