The difference between Vd and Vss
There are many terms used to represent volume of distribution, but two common ones are…
Certara2011 年 3 月 31 日
What is Shrinkage?
In 2007, Mats Karlsson and Radojka Savic published a perspective in Clinical Pharmacology & Therapeutics…
Certara2011 年 3 月 29 日
Is a Monte Carlo Simulation an Exotic Drink?
The term “Monte Carlo simulation” is often used in the modeling and simulation literature with…
Certara2011 年 3 月 21 日
What is WinNonlin?
A reader suggested that I write a similar post about WinNonlin. Great idea! Thank you!…
Certara2011 年 3 月 16 日
Blood or Plasma? Which Should You Assay for Drug Concentration?
Explore blood vs. plasma drug concentration assays. Learn their differences, relationships, and impact on accurate…
Certara2011 年 2 月 19 日
Why should you evaluate dose proportionality?
Dose proportionality is a common phrase used pharmacokinetics. Early in the pre-clinical development process, we…
Certara2011 年 2 月 17 日
What is the Difference Between PK and TK?
Explore the key differences between pharmacokinetics (PK) and toxicokinetics (TK), their roles in drug development,…
Certara2011 年 2 月 15 日
Why are PK Parameters Lognormally Distributed?
The statistical analysis of pharmacokinetic parameters is often overlooked and not always well understood. The…
Certara2011 年 2 月 10 日
What are Direct and Indirect Pharmacodynamic Models?
When constructing pharmacodynamic (PD) models, you will often encounter the adjectives “direct” and “indirect” describing…
Certara2011 年 2 月 8 日
