Modeling and Simulation - PK/PD Archives | 第 19 页，共 38 页

Publication

Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-release Tablets to Elderly and Young Subjects

Tramadol is frequently used in geriatric patients; however, pharmacokinetic (PK) publications on tramadol and O-desmethyltramadol…

Certara2015 年 10 月 27 日

Knowledge Base

9 Things Your Boss Wishes You Knew About PK/PD Modeling

Over the course of my career, I have taught the theory and practical applications of PK/PD…

Certara2015 年 9 月 15 日

Publication

Modeling & Simulation Relating Survival to Tumor Growth Inhibition in Patients

The published OS model and resultant simulations can be leveraged to support Phase II design…

Certara2015 年 9 月 1 日

Knowledge Base

Derivation for Logarithmic Trapezoidal AUC Calculation

Calculating area under the curve requires the use of two separate equations: one is follows…

Certara2015 年 8 月 5 日

Publication

Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium Tuberculosis

Certara2015 年 7 月 23 日

Publication

Population Pharmacokinetic Modeling of Motesanib and Its Active Metabolite, M4, in Cancer Patients

Motesanib is a small molecule and potent multikinase inhibitor with antiangiogenic and antitumor activity. Population…

Certara2015 年 7 月 23 日

Publication

Population Pharmacokinetic Analysis of Thrombomodulin Alfa to Support Dosing Rationale in Patients with Renal Impairment

Thrombomodulin alfa is a soluble recombinant human thrombomodulin that was reported to enhance the reversal…

Certara2015 年 5 月 1 日

Publication

Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis

Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than…

Certara2015 年 5 月 1 日

Blog

儿科用药剂量：小患者，大挑战

儿科药物开发的挑战与复杂性已广为人知。Pharmacometric modeling and simulation (M&S)…

Certara2015 年 4 月 23 日

Publication

Effect of Age and Sex on the Pharmacokinetics and Safety of Avibactam in Healthy Volunteers

Avibactam is a novel non-β-lactam β-lactamase inhibitor currently being assessed in combination with ceftazidime, ceftaroline…

Certara2015 年 4 月 1 日

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Modeling and Simulation – PK/PD

Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-release Tablets to Elderly and Young Subjects

9 Things Your Boss Wishes You Knew About PK/PD Modeling

Modeling & Simulation Relating Survival to Tumor Growth Inhibition in Patients

Derivation for Logarithmic Trapezoidal AUC Calculation

Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium Tuberculosis

Population Pharmacokinetic Modeling of Motesanib and Its Active Metabolite, M4, in Cancer Patients

Population Pharmacokinetic Analysis of Thrombomodulin Alfa to Support Dosing Rationale in Patients with Renal Impairment

Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis

儿科用药剂量：小患者，大挑战

Effect of Age and Sex on the Pharmacokinetics and Safety of Avibactam in Healthy Volunteers

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