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RAPS 赞助的网络广播：优化儿科肿瘤药物研发：全面综述

Developing safe and effective oncology medications for children presents unique challenges due to ethical considerations…

Certara2024 年 10 月 17 日

Blog

日本儿科药物开发方法：您需要了解的信息

Access to safe and effective medications is critical for pediatric patients, yet 60-70% of medicines…

Certara2023 年 5 月 22 日

Case Study

Using Modeling & Simulation to Develop a Dosing Regimen for a Bispecific Antibody for Pediatric Cancer

Bispecific antibodies are an emerging class of antibodies developed in recent years that provide new…

Certara2023 年 1 月 23 日

Blog

Reflections on the recent ICH E11A pediatric extrapolation guideline

The ICH E11A draft Guideline on Paediatric Extrapolation was released on 4 April 2022 entering a public…

Certara2022 年 6 月 14 日

Case Study

Simcyp Simulator 有助于优化成人和青少年孤儿病患者的用药剂量

全世界约有 400,000 名先天性肾上腺增生症（CAH）患者。Current therapy for CAH uses a…

Certara2022 年 6 月 6 日

Case Study

PBPK Modeling in Adults Enables DDI Risk Assessment in Children with SMA

In 2020, the US FDA approved Risdiplam (Evrysdi®) as the first orally administered drug to…

Certara2022 年 6 月 2 日

Blog

Pediatric drug development: Optimizing extrapolation

Drug development in pediatrics continues to be a substrate for the application of innovative tools…

Certara2021 年 9 月 1 日

Case Study

使用 Simcyp Simulator 确定 Guanfacine 在儿童中的药物相互作用风险

Guanfacine (Intuniv® XR) extended release (GXR) is an orally administered, selective alpha2A-adrenergic receptor agonist, non-stimulant…

Certara2021 年 8 月 26 日

Case Study

Using a PBPK-PD Receptor Occupancy Model to Determine the Optimal Dose of Radiprodil for Neonates

Radiprodil is a selective allosteric modulator of the NR2B N-methyl-D-aspartate receptor GluN2B-NMDA that was being…

Certara2021 年 8 月 26 日

Case Study

Bridging Formulations of Quetiapine for Children with Schizophrenia or Bipolar Disorder

Quetiapine is an atypical antipsychotic for treating schizophrenia, bipolar depression, bipolar mania that helps to…

Certara2021 年 8 月 26 日

儿科

RAPS 赞助的网络广播：优化儿科肿瘤药物研发：全面综述

日本儿科药物开发方法：您需要了解的信息

Using Modeling & Simulation to Develop a Dosing Regimen for a Bispecific Antibody for Pediatric Cancer

Reflections on the recent ICH E11A pediatric extrapolation guideline

Simcyp Simulator 有助于优化成人和青少年孤儿病患者的用药剂量

PBPK Modeling in Adults Enables DDI Risk Assessment in Children with SMA

Pediatric drug development: Optimizing extrapolation

使用 Simcyp Simulator 确定 Guanfacine 在儿童中的药物相互作用风险

Using a PBPK-PD Receptor Occupancy Model to Determine the Optimal Dose of Radiprodil for Neonates

Bridging Formulations of Quetiapine for Children with Schizophrenia or Bipolar Disorder

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