How Does the In Vivo Biliary Elimination of Drugs Change with Age? Evidence from In Vitro and Clinical Data Using a Systems Pharmacology Approach
Information on the developmental changes in biliary excretion (BE) of drugs is sparse. The aims…
Certara2016 年 7 月 1 日
Considering Age Variation When Coining Drugs as High Versus Low Hepatic Extraction Ratio
The hepatic extraction ratio (EH) is commonly considered an "inherent attribute" of drug. It determines…
Certara2016 年 7 月 1 日
Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis
Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than…
Certara2015 年 5 月 1 日
Prediction of Voriconazole Non-linear Pharmacokinetics Using a Pediatric Physiologically-based Pharmacokinetic Modeling Approach
We read with interest the report by Zane and Thakker entitled ‘‘A PBPK model for…
Certara2015 年 5 月 1 日
Pediatric Drug Dosing: Tackling Big Problems for Little Patients
儿科药物开发的挑战与复杂性已广为人知。Pharmacometric modeling and simulation (M&S)…
Certara2015 年 4 月 23 日
Vigabatrin Pediatric Dosing Information for Refractory Complex Partial Seizures: Results from a Population Dose-response Analysis
We predicted vigabatrin dosages for adjunctive therapy for pediatric patients with refractory complex partial seizures…
Certara2014 年 12 月 1 日
Meropenem in Children Receiving Continuous Renal Replacement Therapy: Clinical Trial Simulations Using Realistic Covariates
Meropenem is frequently prescribed in children receiving continuous renal replacement therapy (CRRT). Fluid overload is…
Certara2014 年 12 月 1 日
Population Pharmacokinetics Analysis of Vigabatrin in Adults and Children with Epilepsy and Children with Infantile Spasms
Vigabatrin is an inhibitor of γ-aminobutyric acid transaminase. The purpose of these analyses was to…
Certara2014 年 11 月 1 日
