Modeling and simulation in pediatric drug development
Published: 2023 年 12 月 21 日 This is the article written in German, published on pharmind.Children's…
Certara2023 年 12 月 21 日
Concurrent determination of anti-microbial and anti-inflammatory drugs in lachrymal fluid and tissue by LC-MS/MS: A potential treatment for microbial keratitis and its PK-PD evaluation
Explore how validated LC‑MS/MS and PK‑PD simulation support pathogen‑specific dosing for microbial keratitis using Phoenix…
Certara2023 年 12 月 13 日
Bioequivalence Study of Capsules versus Film Tablets Containing Rivaroxaban in Healthy Caucasian Subjects under Fasting and Fed Conditions
Discover how capsule and tablet rivaroxaban formulations are bioequivalent with comparable safety, analysed using Phoenix…
Certara2023 年 11 月 23 日
Unveiling the Influence of a High-Fat Meal on the Pharmacokinetics of Oral Globalagliatin, A Glucokinase Activator, in Healthy Chinese Volunteers
See how high‑fat meals increase globalagliatin exposure by 25–35%, supporting food‑related dosing guidance using Phoenix…
Certara2023 年 11 月 20 日
Population pharmacokinetics of rivaroxaban in Chinese deep vein thrombosis patients and the exposure simulation for dosing recommendation.
Learn how eGFR strongly influences rivaroxaban clearance; PopPK modelling supports renal‑based dose reductions using Phoenix…
Certara2023 年 11 月 11 日
Association Study of Esomeprazole Pharmacokinetics and CYP2C19 Gene Polymorphisms
Find out how CYP2C19 polymorphisms significantly affect esomeprazole exposure and half‑life, analysed using Phoenix WinNonlin.
Certara2023 年 9 月 29 日
Population Pharmacokinetics and Pharmacogenetics Analyses of Dasatinib in Chinese Patients with Chronic Myeloid Leukemia
Explore how age increases dasatinib exposure; PopPK modelling supports lower dosing in elderly Chinese CML…
Certara2023 年 9 月 19 日
Population pharmacokinetics and pharmacogenetics analyses of imatinib in Chinese patients with chronic myeloid leukemia in a real-world situation
Discover how hemoglobin and eGFR drive imatinib PK variability; PopPK modelling supports caution in renal…
Certara2023 年 8 月 25 日
Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study
See how active uptake occurs at both BBB and BCSFB with no sex differences, analysed…
Certara2023 年 8 月 23 日
