Publication

Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors

Discover how PopPK modelling supports dose‑adjustment considerations for ORIN1001 based on bilirubin and lean body…

Certara2024 年 3 月 4 日

Blog

靶向放射治疗的剂量优化考量

The acquisitions of targeted radiation therapy companies (TRT) Point Biopharma by Eli Lilly and RayzeBio…

Certara2024 年 2 月 16 日

Publication

Pharmacokinetic – toxicodynamic Modeling to Elucidate the Involvement of Dorsal Root Ganglion Neuron in Oxaliplatin – induced Peripheral Neurpathu

See how DRG‑based PK‑TD modelling predicts neuropathy severity and supports safer oxaliplatin dosing strategies using…

Certara2024 年 2 月 1 日

Publication

Comparative simulation of intraperitoneal aminoglycoside regimens for patients with peritonitis on automated peritoneal dialysis

Learn how both regimens achieve PK/PD targets; fixed‑dose regimen recommended with trough monitoring, modelled using…

Certara2024 年 1 月 30 日

Publication

The in vivo study on antioxidant activity of wendan decoction in treating hyperlipidemia: a pharmacokinetic-pharmacodynamic (PK-PD) model

Find out how PK‑PD modelling shows delayed lipid‑lowering effects driven by key flavonoids in Wendan…

Certara2024 年 1 月 23 日

Publication

Population Pharmacokinetics and Individualized Medication of Azithromycin for Injection in Children Under 6 Years Old

Explore how weight and age drive azithromycin PK variability; PopPK modelling supports personalized dosing using…

Certara2024 年 1 月 20 日

Publication

Population pharmacokinetics of rotigotine extended‑release microspheres for intramuscular injection in early‑stage Parkinson’s disease

Discover how body weight meaningfully affects rotigotine ER exposure; race has minimal impact, modelled using…

Certara2024 年 1 月 17 日

Publication

Effect of High-Fat Meal on the Pharmacokinetics and Safety of Valsartan/Amlodipine Fixed Dose Combination Tablets in Healthy Subjects

See how high‑fat meals reduce valsartan exposure by over 50% while amlodipine PK is unaffected,…

Certara2024 年 1 月 11 日

Publication

Population pharmacokinetic modeling of ilaprazole in healthy subjects and patients with duodenal ulcer in China

Learn how the first Chinese PopPK model shows weight, sex, and ulcer status influence ilaprazole…

Certara2024 年 1 月 10 日

Publication

Simultaneous determination of amphotericin B, tobramycin and vancomycin in rabbit ocular biofluids and tissues by LC-MS/MS: An antimicrobial therapy for keratitis and its PK-PD application

Find out how triple‑drug ocular PK‑PD modelling identifies optimal dosing frequency for keratitis therapy using…

Certara2023 年 12 月 31 日

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Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors

靶向放射治疗的剂量优化考量

Pharmacokinetic – toxicodynamic Modeling to Elucidate the Involvement of Dorsal Root Ganglion Neuron in Oxaliplatin – induced Peripheral Neurpathu

Comparative simulation of intraperitoneal aminoglycoside regimens for patients with peritonitis on automated peritoneal dialysis

The in vivo study on antioxidant activity of wendan decoction in treating hyperlipidemia: a pharmacokinetic-pharmacodynamic (PK-PD) model

Population Pharmacokinetics and Individualized Medication of Azithromycin for Injection in Children Under 6 Years Old

Population pharmacokinetics of rotigotine extended‑release microspheres for intramuscular injection in early‑stage Parkinson’s disease

Effect of High-Fat Meal on the Pharmacokinetics and Safety of Valsartan/Amlodipine Fixed Dose Combination Tablets in Healthy Subjects

Population pharmacokinetic modeling of ilaprazole in healthy subjects and patients with duodenal ulcer in China

Simultaneous determination of amphotericin B, tobramycin and vancomycin in rabbit ocular biofluids and tissues by LC-MS/MS: An antimicrobial therapy for keratitis and its PK-PD application

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