Applications of Quantitative Systems Pharmacology Modeling for Vaccine Development

Vaccines play a crucial role in preventing diseases and thereby saving countless lives. To prevent the spread of diseases, it is important that vaccines are broadly available in all parts of the world. However, the development of vaccines is expensive and time-consuming, limiting the availability of vaccines. We use our Vaccine Model to predict optimal dosing schemes for clinical trials in both adult and paediatric populations. We demonstrate how our Vaccine Model could have supported vaccine development for SARS-Cov-2 to reduce cost and time and could have been used to prevent costly trial extensions.