Certara’s Immuno-oncology (IO) Simulator is a cutting-edge QSP modeling platform designed to predict optimal drug combinations, dosing regimens, and biomarkers in virtual patients. By simulating the complex dynamics of the Cancer Immunity Cycle, the IO Simulator empowers researchers to make data-driven decisions for immuno-oncology therapies. This innovative tool integrates pre-clinical data to refine models and forecast clinical outcomes, enabling the development of personalized treatment strategies for specific indications and tumor phenotypes.
Immuno-oncology Simulator™
Revolutionizing immuno-oncology with predictive modeling
Learn more about the Immuno-oncology Simulator
Simulates tumor, lymph, and blood compartments
Models interactions between tumor cells, T cells, dendritic cells, macrophages, NK cells, and cytokines
Supports drug modalities including mAb, bsAb, ADC, and small molecules
Features of the IO Simulator immuno-oncology modeling platform
The IO Simulator offers a mechanistic model of the Cancer Immunity Cycle, delivered through QSP Designer software. It facilitates modular development of a compound’s mechanism of action, calibrated with pre-clinical data, and integrates these models to predict clinical outcomes. Virtual trials conducted with the IO Simulator account for tumor heterogeneity, providing insights into optimal dosing and patient stratification biomarkers.
Modules of IO Simulator
- Tumor, lymph, and blood compartments
- Tumor cells
- T cells
- Dendritic cells
- Macrophages
- NK cells
- Multiple cytokines
Drug modalities
- mAb
- bsAb
- ADC
- 小分子药物
对话 QSP 专家
1 / 1
专家
Andrzej Kierzek
VP, QSP R&D
Driving innovation in QSP with 25+ years of expertise in molecular and systems biology, leading a team of 20+ scientists to build cutting-edge models and knowledgebases
建立联系相关资源
查看全部Explore our other QSP platform models
Certara offers Quantitative Systems Pharmacology (QSP) platform models across diverse therapeutic areas, enabling data-driven insights to accelerate drug development. 我们的定制化方案整合复杂生物系统，支持从研究到临床的全链条决策优化。
Speak to a QSP expert
Ask us how the IO Simulator can build confidence into your immuno-oncology therapies.
Predict optimal drug combinations and dosing regimens
Identify patient stratification biomarkers for personalized therapies
Simulate clinical outcomes with unparalleled precision
