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通过 PBPK 模型提升药物发现的信心

日期： 2025 年 8 月 21 日, 星期四

时间： 11am-12pm ET

Services: Simcyp® PBPK Modeling

产品： Simcyp® Discovery

Introducing structure-based predictors, dose finding tool, and Ask Simcyp chat

Join leading PBPK experts to explore the latest trends in applying physiologically based pharmacokinetic (PBPK) modeling to accelerate early drug discovery and enhance confidence in pre-IND decision-making.

Key Topics Include:

  • Trends in Drug Discovery: Learn how PBPK modeling is being adopted earlier in the drug development process to triage best drug candidates, support first-in-human PK prediction, assess potential drug-drug interaction and formulation risks, and more.
  • Simcyp Discovery Version 2: Certara’s advanced PBPK platform for pre-IND success introduces major updates to improve usability, automation, and model development. Updates include:

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    • Automation and Documentation Enhancements: New workflow tools such as the Dose Finding Tool streamline and speed up model development and help identify optimal dosing strategies to meet PK/PD targets.
    • Structure-Based Predictors: Use SMILES strings to predict key physicochemical properties.
    • Expanded Static DDI Capabilities: Inclusion of Desipramine (CYP2D6 substrate) and Paroxetine (competitive and mechanism-based CYP2D6 inhibitor) in the static DDI tool.
    • Performance Upgrades: Enhanced user experience with GPT-powered ‘Ask Simcyp’ help and new Simcyp Cloud simulation services.
    • Usability Improvements: Realtime reporting of simulation results withing the Simulator, improved user experience.

Whether you’re a new or experienced user, this session will provide practical insights on how to integrate Simcyp Discovery into your preclinical workflows and stay at the forefront of model-informed drug development.

演讲嘉宾：

Aki Heikkinen, PhD

Aki Heikkinen, PhD

Claire Ciana, PhD

Senior Research Scientist, Certara

Freddy Chen, PhD

Director of PBPK Consultancy, Certara

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