Relationship Between Exposure to Sunitinib and Efficacy and Tolerability Endpoints in Patients with Cancer: Results of a Pharmacokinetic/Pharmacodynamic Meta-analysis Publication Relationship Between Exposure to Sunitinib and Efficacy and Tolerability Endpoints in Patients with Cancer: Results of a Pharmacokinetic/Pharmacodynamic Meta-analysis In this pharmacokinetic/pharmacodynamic meta-analysis, we investigated relationships between clinical endpoints and sunitinib exposure in patients…Certara2010 年 7 月 1 日
Pharmacology and Safety of Glycerol Phenylbutyrate in Healthy Adults and Adults with Cirrhosis Publication Pharmacology and Safety of Glycerol Phenylbutyrate in Healthy Adults and Adults with Cirrhosis Phenylbutyric acid (PBA), which is approved for treatment of urea cycle disorders (UCDs) as sodium…Certara2010 年 6 月 1 日
Under-reporting of Venous and Arterial Thrombotic Events in Randomized Clinical Trials: A Meta-analysis Publication Under-reporting of Venous and Arterial Thrombotic Events in Randomized Clinical Trials: A Meta-analysis For the detection of unwanted outcomes of new interventions, physicians rely on adverse event reporting.…Certara2010 年 3 月 1 日
Detection of Lymph Node Metastases by Gadolinium-enhanced Magnetic Resonance Imaging: Systematic Review and Meta-analysis Publication Detection of Lymph Node Metastases by Gadolinium-enhanced Magnetic Resonance Imaging: Systematic Review and Meta-analysis Gadolinium-based contrast agents are used with magnetic resonance imaging (MRI) to highlight tumor vascularity in…Certara2010 年 2 月 24 日
The Use of Biosimulation in the Design of a Novel Multilevel Weight Loss Maintenance Program for Overweight Children Publication The Use of Biosimulation in the Design of a Novel Multilevel Weight Loss Maintenance Program for Overweight Children Weight loss outcomes achieved through conventional behavior change interventions are prone to deterioration over time.…Certara2010 年 2 月 18 日
Population Pharmacokinetics of Teduglutide Following Repeated Subcutaneous Administrations in Healthy Participants and in Patients with Short Bowel Syndrome and Crohn’s Disease Publication Population Pharmacokinetics of Teduglutide Following Repeated Subcutaneous Administrations in Healthy Participants and in Patients with Short Bowel Syndrome and Crohn’s Disease Teduglutide is a GLP-2 analog currently evaluated for the treatment of short bowel syndrome, Crohn's…Certara2010 年 1 月 1 日
Clinical Trial Simulations in Pediatric Patients Using Realistic Covariates: Application to Teduglutide, a Glucagon-like Peptide-2 Analog in Neonates and Infants with Short-bowel Syndrome Publication Clinical Trial Simulations in Pediatric Patients Using Realistic Covariates: Application to Teduglutide, a Glucagon-like Peptide-2 Analog in Neonates and Infants with Short-bowel Syndrome Teduglutide, a synthetic glucagon-like peptide-2 (GLP-2) analog with activity relating to the regeneration, maintenance, and…Certara2009 年 12 月 1 日
In Vitro Inhibition of Multiple Cytochrome P450 Isoforms by Xanthone Derivatives from Mangosteen Extract Publication In Vitro Inhibition of Multiple Cytochrome P450 Isoforms by Xanthone Derivatives from Mangosteen Extract Mangosteen is a xanthone-containing fruit found in Southeast Asia for which health claims include maintaining healthy immune…Certara2009 年 9 月 1 日
Model-based Prediction of Phase 3 Overall Survival in Colorectal Cancer on the Basis of Phase 2 Tumor Dynamics Publication Model-based Prediction of Phase 3 Overall Survival in Colorectal Cancer on the Basis of Phase 2 Tumor Dynamics We developed a drug-disease simulation model to predict antitumor response and overall survival in phase…Certara2009 年 9 月 1 日
Excluding Venous Thromboembolism Using Point of Care D-dimer Tests in Outpatients: A Diagnostic Meta-analysis Publication Excluding Venous Thromboembolism Using Point of Care D-dimer Tests in Outpatients: A Diagnostic Meta-analysis This article is a review the evidence on the diagnostic accuracy of the currently available…Certara2009 年 8 月 14 日