Pharmacokinetic Predictions in Children by Using the Physiologically-based Pharmacokinetic Modeling Publication Pharmacokinetic Predictions in Children by Using the Physiologically-based Pharmacokinetic Modeling Nowadays, 50-90% of drugs used in children have never been actually studied in this population. Consequently, either…Certara2008 年 12 月 1 日
The Effects of CYP3A4 Inhibition on Erlotinib Pharmacokinetics: Computer-based Simulation (Simcyp) Predicts In Vivo Metabolic Inhibition Publication The Effects of CYP3A4 Inhibition on Erlotinib Pharmacokinetics: Computer-based Simulation (Simcyp) Predicts In Vivo Metabolic Inhibition BACKGROUND: Erlotinib is an orally active antitumor agent. Analyses in vitro using human liver microsomes and…Certara2008 年 1 月 1 日
Physiologically-based Approaches Towards the Prediction of Pharmacokinetics: In Vitro-In Vivo Extrapolation Publication Physiologically-based Approaches Towards the Prediction of Pharmacokinetics: In Vitro-In Vivo Extrapolation In adapting to the challenge to make more informed selection of compounds for development, the…Certara2007 年 12 月 1 日