Mechanistic Surface pH Modelling Improves PBPK Prediction of a Weakly Acidic Drug: Case Study of Bempedoic Acid Poster Mechanistic Surface pH Modelling Improves PBPK Prediction of a Weakly Acidic Drug: Case Study of Bempedoic Acid Explore how mechanistic surface pH modeling in Simcyp improves PBPK prediction of dissolution-controlled absorption for…Certara2026 年 6 月 26 日
Dermal PBPK Modelling of Propylparaben with a Novel Skin Metabolism Framework Poster Dermal PBPK Modelling of Propylparaben with a Novel Skin Metabolism Framework Explore how a mechanistic dermal PBPK model with experimentally scaled, layer-specific skin metabolism predicts propylparaben…Certara2026 年 6 月 26 日
Application of PBPK Modelling to Explore Complex Food Effects on Trospium Chloride Pharmacokinetics Poster Application of PBPK Modelling to Explore Complex Food Effects on Trospium Chloride Pharmacokinetics Discover how PBPK modeling with Simcyp mechanistically explains the formulation-dependent negative food effect of trospium…Certara2026 年 6 月 26 日
Cross-Version Simcyp Simulator Performance Assessment Using a Bioequivalence Framework for EMA Qualification Poster Cross-Version Simcyp Simulator Performance Assessment Using a Bioequivalence Framework for EMA Qualification Learn how Certara used a bioequivalence-based TOST framework to demonstrate that Simcyp Simulator versions V20–V24…Certara2026 年 6 月 26 日
PBPK Modelling of Bispecific Monoclonal Antibody Tumour Targeting Specificity Poster 双特异性单克隆抗体肿瘤靶向特异性的 PBPK 建模 Explore how PBPK modelling evaluates the in vivo tumour-targeting specificity of bispecific monoclonal antibodies (bsmAbs),…Certara2026 年 6 月 25 日
Sex-Specific Bioequivalence Outcomes: PBPK Insights into Gastric Emptying Variability Poster 性别特异性生物等效性结果:基于 PBPK 模型对胃排空变异性的见解 Discover how sex-dependent within-subject variability in gastric emptying time influences supersaturation, precipitation, and Cmax in…Certara2026 年 6 月 25 日
PBPK Modelling of Formulation-Dependent Food Effects for Itraconazole Oral Solution Poster 伊曲康唑(Itraconazole)口服溶液剂型相关食物效应的 PBPK 建模 Explore mechanistic PBPK modelling of itraconazole oral solution, revealing how bile salt–cyclodextrin interactions drive a…Certara2026 年 6 月 25 日
Integrating Endogenous Ligand Competition into a Mechanistic Whole-Body PBPK Model of Therapeutic Monoclonal Antibodies Poster 将内源性配体竞争纳入治疗性单克隆抗体的机制全身 PBPK 模型 Discover how endogenous ligand competition was incorporated into a whole-body PBPK model to improve prediction…Certara2026 年 6 月 23 日
Machine Learning based drug renal clearance predictor development and application Poster Machine Learning based drug renal clearance predictor development and application A machine learning QSAR model predicts human renal clearance from simple, easy-to-obtain inputs and sharpens…Certara2026 年 6 月 22 日
2026 Simcyp Workshops Brochure 2026 Simcyp Workshops Advance your PBPK and model-informed drug development expertise with Simcyp workshops. Learn from experts through…Certara2026 年 6 月 11 日