More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-mediated Clearances Publication More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-mediated Clearances Rosuvastatin is a substrate of choice in clinical studies of organic anion-transporting polypeptide (OATP)1B1- and…Danielle Pillsbury2016 年 7 月 1 日
Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data Publication Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data A 4-compartment permeability-limited brain (4Brain) model consisting of brain blood, brain mass, cranial and spinal…Danielle Pillsbury2016 年 6 月 1 日
Metformin and Cimetidine: Physiologically-based Pharmacokinetic Modeling to Investigate Transporter Mediated Drug–drug Interactions Publication Metformin and Cimetidine: Physiologically-based Pharmacokinetic Modeling to Investigate Transporter Mediated Drug–drug Interactions Danielle Pillsbury2016 年 6 月 1 日
Prediction of Drug-drug Interactions Arising From CYP3A Induction Using a Physiologically-based Dynamic Model Publication Prediction of Drug-drug Interactions Arising From CYP3A Induction Using a Physiologically-based Dynamic Model Using physiologically-based pharmacokinetic modeling, we predicted the magnitude of drug-drug interactions (DDIs) for studies with…Danielle Pillsbury2016 年 6 月 1 日
Cardiac Safety Simulator Brochure 心脏安全模拟器 及早预测药物引发的心血管风险,从而做出明智的决策,减少代价高昂的后期失败。Danielle Pillsbury2016 年 4 月 27 日
Recent Advances in Development and Application of Physiologically-based Pharmacokinetic (PBPK) Models: A Transition from Academic Curiosity to Regulatory Acceptance Publication Recent Advances in Development and Application of Physiologically-based Pharmacokinetic (PBPK) Models: A Transition from Academic Curiosity to Regulatory Acceptance There is a renewed surge of interest in applications of physiologically-based pharmacokinetic (PBPK) models by the…Danielle Pillsbury2016 年 4 月 14 日
Inside the Mind of Pharmacometrics Pioneer, Professor Malcolm Rowland Blog Inside the Mind of Pharmacometrics Pioneer, Professor Malcolm Rowland Officially, Prof. Malcolm Rowland has retired. This scientific pioneer has been helping lay the foundation…Certara2016 年 2 月 23 日
Conventional & Mechanistic IVIVC: Complementary or Clashing Methods? 博客 Conventional & Mechanistic IVIVC: Complementary or Clashing Methods? An IVIVC (in vitro-in vivo correlation) is a mathematical relationship that predicts key pharmacokinetic parameters…Certara2016 年 2 月 9 日
A Bottom-up Whole-body Physiologically-based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins Publication A Bottom-up Whole-body Physiologically-based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins Danielle Pillsbury2016 年 1 月 1 日
Modeling the Influence of Ethnicity on Drug Disposition Blog Modeling the Influence of Ethnicity on Drug Disposition Ever noticed how people from different ethnic backgrounds respond differently to drugs? For example, you…Certara2015 年 11 月 23 日