Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data Publication Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data A 4-compartment permeability-limited brain (4Brain) model consisting of brain blood, brain mass, cranial and spinal…webdev2016 年 6 月 1 日
Metformin and Cimetidine: Physiologically-based Pharmacokinetic Modeling to Investigate Transporter Mediated Drug–drug Interactions Publication Metformin and Cimetidine: Physiologically-based Pharmacokinetic Modeling to Investigate Transporter Mediated Drug–drug Interactions webdev2016 年 6 月 1 日
Prediction of Drug-drug Interactions Arising From CYP3A Induction Using a Physiologically-based Dynamic Model Publication Prediction of Drug-drug Interactions Arising From CYP3A Induction Using a Physiologically-based Dynamic Model Using physiologically-based pharmacokinetic modeling, we predicted the magnitude of drug-drug interactions (DDIs) for studies with…webdev2016 年 6 月 1 日
Recent Advances in Development and Application of Physiologically-based Pharmacokinetic (PBPK) Models: A Transition from Academic Curiosity to Regulatory Acceptance Publication Recent Advances in Development and Application of Physiologically-based Pharmacokinetic (PBPK) Models: A Transition from Academic Curiosity to Regulatory Acceptance There is a renewed surge of interest in applications of physiologically-based pharmacokinetic (PBPK) models by the…webdev2016 年 4 月 14 日
Inside the Mind of Pharmacometrics Pioneer, Professor Malcolm Rowland Blog Inside the Mind of Pharmacometrics Pioneer, Professor Malcolm Rowland Officially, Prof. Malcolm Rowland has retired. This scientific pioneer has been helping lay the foundation…Certara2016 年 2 月 23 日
Conventional & Mechanistic IVIVC: Complementary or Clashing Methods? 博客 Conventional & Mechanistic IVIVC: Complementary or Clashing Methods? An IVIVC (in vitro-in vivo correlation) is a mathematical relationship that predicts key pharmacokinetic parameters…Certara2016 年 2 月 9 日
A Bottom-up Whole-body Physiologically-based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins Publication A Bottom-up Whole-body Physiologically-based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins webdev2016 年 1 月 1 日
Modeling the Influence of Ethnicity on Drug Disposition Blog Modeling the Influence of Ethnicity on Drug Disposition Ever noticed how people from different ethnic backgrounds respond differently to drugs? For example, you…Certara2015 年 11 月 23 日
Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model Publication Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model Bioavailability of orally administered drugs can be influenced by a number of factors including release…webdev2015 年 11 月 1 日