Prediction of Midazolam Pharmacokinetics in Pregnant Women with Coeliac Disease using Simcyp Pregnancy PBPK Model Poster Prediction of Midazolam Pharmacokinetics in Pregnant Women with Coeliac Disease using Simcyp Pregnancy PBPK Model Danielle Pillsbury2019 年 8 月 23 日
Investigating Impacts of Model Parameters Correlations in Global Sensitivity Analysis: Determining the Most Influential Parameters of a Minimal PBPK Model of Midazolam Poster Investigating Impacts of Model Parameters Correlations in Global Sensitivity Analysis: Determining the Most Influential Parameters of a Minimal PBPK Model of Midazolam Danielle Pillsbury2019 年 6 月 24 日
PBPK’s Pivotal Role in Modern Drug Development: Busting Common Myths and Misconceptions White Paper PBPK’s Pivotal Role in Modern Drug Development: Busting Common Myths and Misconceptions This white paper addresses common PBPK myths and misconceptions and demonstrates how this approach is…Danielle Pillsbury2019 年 2 月 4 日
Using PBPK Models to Assess Fetal Drug Exposure Blog Using PBPK Models to Assess Fetal Drug Exposure The tragedy of thalidomide provides a cautionary tale about the potential for birth defects resulting…Certara2018 年 1 月 19 日
PBPK Modeling and Simulation for Biologics Brochure 用于生物制剂的 PBPK 建模和模拟 Danielle Pillsbury2017 年 4 月 28 日
Application of the MechPeff Model to Predict Passive Effective Intestinal Permeability in the Different Regions of the Rodent Small Intestine and Colon Publication Application of the MechPeff Model to Predict Passive Effective Intestinal Permeability in the Different Regions of the Rodent Small Intestine and Colon Danielle Pillsbury2017 年 2 月 1 日
Commentary on “In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-based Absorption Models” Publication Commentary on “In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-based Absorption Models” Danielle Pillsbury2017 年 1 月 1 日
Assessing Drug-Smoking Interactions Using PBPK Modeling Blog Assessing Drug-Smoking Interactions Using PBPK Modeling The prevalence of cigarette smoking remains high globally despite abundant evidence showing that it isn't…Certara2016 年 7 月 29 日
Towards a Best Practice Approach in PBPK Modeling: Case Example of Developing a Unified Efavirenz Model Accounting for Induction of CYPs 3A4 and 2B6 Publication Towards a Best Practice Approach in PBPK Modeling: Case Example of Developing a Unified Efavirenz Model Accounting for Induction of CYPs 3A4 and 2B6 Danielle Pillsbury2016 年 7 月 20 日
Status of QSP Modeling in the Pharmaceutical Industry Blog Status of QSP Modeling in the Pharmaceutical Industry A primary cause of failures in pharmaceutical research and development (R&D) has been attributed to…Certara2016 年 7 月 6 日