What Can We Learn from a Human Mass Balance Study?
Mass balance studies are also called “C-14 studies” or “Absorption, Metabolism, and Excretion (AME) studies”.…
Certara2012 年 11 月 27 日
Simulations Using a Drug-disease Modeling Framework and Phase 2 Data Predict Phase 3 Survival Outcome in First-line Non-small Cell Lung Cancer
Simulations were performed for carboplatin/paclitaxel (C/P) plus motesanib or bevacizumab vs. C/P as first-line treatment…
Certara2012 年 11 月 1 日
Characterization of Exposure Versus Response of Edoxaban in Patients Undergoing Total Hip Replacement Surgery
Edoxaban is an oral direct factor Xa inhibitor approved for the prevention of venous thromboembolism…
Certara2012 年 11 月 1 日
Trends in Oral Drug Bioavailability Following Bariatric Surgery: Examining the Variable Extent of Impact on Exposure of Different Drug Classes
Changes to oral drug bioavailability have been observed post bariatric surgery. However, the magnitude and…
Certara2012 年 11 月 1 日
Designing a Clinical Drug-drug Interaction Study
After a much longer delay that I expected, I am back to blogging on a…
Certara2012 年 10 月 29 日
A Pregnancy Physiologically-based Pharmacokinetic (p-PBPK) Model for Disposition of Drugs Metabolized by CYP1A2, CYP3A4, and CYP2D6
Pregnant women are usually not part of the traditional drug development program. Pregnancy is associated…
Certara2012 年 10 月 9 日
Ontogeny of Oral Drug Absorption Processes in Children
A large proportion of prescribed drugs to children are administered orally. Age-related change in factors…
Certara2012 年 10 月 8 日
Physiologically-based Modeling of Pravastatin Transporter-mediated Hepatobiliary Disposition and Drug-drug Interactions
To develop physiologically based pharmacokinetic (PBPK) model to predict the pharmacokinetics and drug-drug interactions (DDI)…
Certara2012 年 10 月 1 日
Methods of Solving Rapid Binding Target-mediated Drug Disposition Model for Two Drugs Competing for the Same Receptor
The target-mediated drug disposition (TMDD) model has been adopted to describe pharmacokinetics for two drugs competing for the same receptor. A rapid binding assumption introduces total receptor and total drug concentrations while free drug concentrations C…
Certara2012 年 10 月 1 日
Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain
A significant barrier to realization of the full potential of clozapine as a therapeutic agent…
Certara2012 年 10 月 1 日
