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Physiologically-based Pharmacokinetic (PBPK) Modeling: It is Here to Stay!

Physiologically based pharmacokinetic (PBPK) modeling is an extremely useful approach with the ability to predict…

Certara2012 年 3 月 1 日

Publication

Interactions Between Buprenorphine and the Protease Inhibitors Darunavir-ritonavir and Fosamprenavir-ritonavir

This study examined drug interactions between buprenorphine, a partial opioid agonist used for opioid dependence…

Certara2012 年 2 月 1 日

Publication

Subcutaneous Absorption of Monoclonal Antibodies: Role of Dose, Site of Injection, and Injection Volume on Rituximab Pharmacokinetics in Rats

To determine the effect of dose, the anatomical site of injection, and the injection volume…

Certara2012 年 2 月 1 日

Publication

Influence of Route of Administration and Liposomal Encapsulation on Blood and Lymph Node Exposure to the Protein VEGF-C156S

VEGF-C156S is a recombinant form of human vascular endothelial growth factor C (VEGF-C), which targets…

Certara2012 年 2 月 1 日

Publication

Effect of Ketoconazole on the Pharmacokinetics of Axitinib in Healthy Volunteers

Axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptors 1,…

Certara2012 年 2 月 1 日

Publication

Phase 1 Safety, Pharmacokinetic and Pharmacodynamic Trial of BMS-599626 (AC480), an Oral Pan-HER Receptor Tyrosine Kinase Inhibitor, in Patients with Advanced Solid Tumors

We studied the safety, tolerability, and recommended dose of BMS-599626, an orally bioavailable inhibitor of…

Certara2012 年 2 月 1 日

Publication

Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression

Objective: Taspine, isolated from Radix et Rhizoma Leonticis has demosntrated potential proctiective effects against cancer.…

Certara2012 年 1 月 1 日

Publication

Brain Uptake of the Drug of Abuse Gamma-hydroxybutyric Acid in Rats

γ-Hydroxybutyric acid (GHB) is an endogenous compound and a substrate for the ubiquitous monocarboxylate transporter…

Certara2012 年 1 月 1 日

Publication

Preliminary Comparison of Sertraline Levels in Postbariatric Surgery Patients Versus Matched Non-surgical Cohort

Roux-en-Y gastric bypass (RYGB) is the most frequent bariatric procedure performed in the United States,…

Certara2012 年 1 月 1 日

Publication

Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite

Clopidogrel is an antiplatelet agent widely used in cardiovascular diseases and an inactive prodrug that…

Certara2012 年 1 月 1 日

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Physiologically-based Pharmacokinetic (PBPK) Modeling: It is Here to Stay!

Interactions Between Buprenorphine and the Protease Inhibitors Darunavir-ritonavir and Fosamprenavir-ritonavir

Subcutaneous Absorption of Monoclonal Antibodies: Role of Dose, Site of Injection, and Injection Volume on Rituximab Pharmacokinetics in Rats

Influence of Route of Administration and Liposomal Encapsulation on Blood and Lymph Node Exposure to the Protein VEGF-C156S

Effect of Ketoconazole on the Pharmacokinetics of Axitinib in Healthy Volunteers

Phase 1 Safety, Pharmacokinetic and Pharmacodynamic Trial of BMS-599626 (AC480), an Oral Pan-HER Receptor Tyrosine Kinase Inhibitor, in Patients with Advanced Solid Tumors

Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression

Brain Uptake of the Drug of Abuse Gamma-hydroxybutyric Acid in Rats

Preliminary Comparison of Sertraline Levels in Postbariatric Surgery Patients Versus Matched Non-surgical Cohort

Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite

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