Blood or Plasma? Which Should You Assay for Drug Concentration?
Explore blood vs. plasma drug concentration assays. Learn their differences, relationships, and impact on accurate…
Certara2011 年 2 月 19 日
Why Should You Evaluate Dose Proportionality?
Dose proportionality is a common phrase used pharmacokinetics. Early in the pre-clinical development process, we…
Certara2011 年 2 月 17 日
What is the Difference Between PK and TK?
Explore the key differences between pharmacokinetics (PK) and toxicokinetics (TK), their roles in drug development,…
Certara2011 年 2 月 15 日
Why are PK Parameters Lognormally Distributed?
The statistical analysis of pharmacokinetic parameters is often overlooked and not always well understood. The…
Certara2011 年 2 月 10 日
What are Direct and Indirect Pharmacodynamic Models?
When constructing pharmacodynamic (PD) models, you will often encounter the adjectives “direct” and “indirect” describing…
Certara2011 年 2 月 8 日
What is Modeling and Simulation?
I am currently attending a short conference on modeling and simulation in pediatric clinical pharmacology,…
Certara2011 年 2 月 1 日
Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides
Polycyclic aromatic hydrocarbons (PAH) are among the likely major causative agents for lung cancer in…
Certara2011 年 2 月 1 日
Relationship Between AUC and Volume of Distribution
A few days ago on the pharmacokinetics listserve PharmPK, the following question appeared: I’m having…
Certara2011 年 1 月 26 日
Where Did the 80-125% Bioequivalence Criteria Come From?
Most people involved in clinical pharmacokinetics are familiar with the 80-125% criterion. This criterion is…
Certara2011 年 1 月 24 日
