Model-based Drug Development in Oncology: What’s Next?
Model-based estimates of tumor growth inhibition (TGI) metrics have the potential to enhance learning in…
Certara2013 年 4 月 1 日
Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide
CS-8635, a fixed-dose triple combination of olmesartan, amlodipine, and hydrochlorothiazide, was developed to address the…
Certara2013 年 4 月 1 日
Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body
When I first began learning about pharmacokinetics, I was often confused by the mean residence…
Certara2013 年 3 月 28 日
Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis
Axitinib is a potent and selective inhibitor of vascular endothelial growth factor receptors 1, 2,…
Certara2013 年 3 月 28 日
The Superposition Principle
Discover the superposition principle and its significance in science and mathematics. Learn how this fundamental…
Certara2013 年 3 月 14 日
Plasma Topiramate Concentrations from Doses Associated with Neuroprotection Against White Matter Injury and Stroke in Two Strains of Rat Pups
Cerebral white matter (WM) injury and stroke are common neuropathological injuries in newborns with congenital…
Certara2013 年 3 月 1 日
Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data
This article reports an analysis that aims to quantify the effect of fingolimod, an oral…
Certara2013 年 3 月 1 日
Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox
Although smallpox has been eradicated, the United States government considers it a "material threat" and…
Certara2013 年 3 月 1 日
Saturable Drug Absorption
Drug absorption is the process by which a drug molecule moves from the site of…
Certara2013 年 2 月 26 日
Nonlinear PK: What Does That Mean?
You may come across a phrase like the following and wonder what it means: “……
Certara2013 年 2 月 17 日
