Population Pharmacokinetic Analysis of Thrombomodulin Alfa to Support Dosing Rationale in Patients with Renal Impairment Publication Population Pharmacokinetic Analysis of Thrombomodulin Alfa to Support Dosing Rationale in Patients with Renal Impairment Thrombomodulin alfa is a soluble recombinant human thrombomodulin that was reported to enhance the reversal…Certara2015 年 5 月 1 日
Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis Publication Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than…Certara2015 年 5 月 1 日
Pediatric Drug Dosing: Tackling Big Problems for Little Patients Blog 儿科用药剂量:小患者,大挑战 儿科药物开发的挑战与复杂性已广为人知。Pharmacometric modeling and simulation (M&S)…Certara2015 年 4 月 23 日
Effect of Age and Sex on the Pharmacokinetics and Safety of Avibactam in Healthy Volunteers Publication Effect of Age and Sex on the Pharmacokinetics and Safety of Avibactam in Healthy Volunteers Avibactam is a novel non-β-lactam β-lactamase inhibitor currently being assessed in combination with ceftazidime, ceftaroline…Certara2015 年 4 月 1 日
Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 Publication Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 RG7652 is a fully humanized monoclonal antibody targeting human PCSK9, a regulator of serum low…Certara2015 年 3 月 31 日
Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Avibactam Alone and in Combination with Ceftazidime in Healthy Male Volunteers: Results of Two Randomized, Placebo-controlled Studies Publication Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Avibactam Alone and in Combination with Ceftazidime in Healthy Male Volunteers: Results of Two Randomized, Placebo-controlled Studies Avibactam is a novel non-β-lactam β-lactamase inhibitor effective against Ambler class A, C and some…Certara2015 年 3 月 27 日
Pharmacokinetics and Safety of Oseltamivir in Patients with End-stage Renal Disease Treated with Automated Peritoneal Dialysis Publication Pharmacokinetics and Safety of Oseltamivir in Patients with End-stage Renal Disease Treated with Automated Peritoneal Dialysis Certara2015 年 3 月 25 日
Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison Between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys Publication Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison Between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on…Certara2015 年 2 月 15 日
Calculating the Elimination Rate Constant BlogKnowledge Base Calculating the Elimination Rate Constant The elimination rate constant is the rate at which drug is cleared from the body…Certara2015 年 2 月 2 日
Population Pharmacokinetics of Ceftolozane/Tazobactam in Healthy Volunteers, Subjects with Varying Degrees of Renal Function and Patients with Bacterial Infections Publication Population Pharmacokinetics of Ceftolozane/Tazobactam in Healthy Volunteers, Subjects with Varying Degrees of Renal Function and Patients with Bacterial Infections Ceftolozane/tazobactam is a novel antipseudomonal cephalosporin and a β-lactamase inhibitor in clinical development for treatment…Certara2015 年 2 月 1 日