Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis Publication Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis Axitinib is a potent and selective inhibitor of vascular endothelial growth factor receptors 1, 2,…Danielle Pillsbury2013 年 3 月 28 日
What is a Loading Dose? BlogKnowledge Base What is a Loading Dose? Drug therapy in chronic disease situations requires systemic drug levels to reach target steady-state levels…Certara2013 年 3 月 22 日
The Superposition Principle Knowledge Base The Superposition Principle Discover the superposition principle and its significance in science and mathematics. Learn how this fundamental…Nathan Teuscher2013 年 3 月 14 日
Plasma Topiramate Concentrations from Doses Associated with Neuroprotection Against White Matter Injury and Stroke in Two Strains of Rat Pups Publication Plasma Topiramate Concentrations from Doses Associated with Neuroprotection Against White Matter Injury and Stroke in Two Strains of Rat Pups Cerebral white matter (WM) injury and stroke are common neuropathological injuries in newborns with congenital…Danielle Pillsbury2013 年 3 月 1 日
Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data Publication Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data This article reports an analysis that aims to quantify the effect of fingolimod, an oral…Danielle Pillsbury2013 年 3 月 1 日
Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox Publication Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox Although smallpox has been eradicated, the United States government considers it a "material threat" and…Danielle Pillsbury2013 年 3 月 1 日
Saturable Drug Absorption Knowledge Base Saturable Drug Absorption Drug absorption is the process by which a drug molecule moves from the site of…Nathan Teuscher2013 年 2 月 26 日
Nonlinear PK: What Does That Mean? BlogKnowledge Base Nonlinear PK: What Does That Mean? You may come across a phrase like the following and wonder what it means: “……Certara2013 年 2 月 17 日
Why Cmax is a Continuous Variable and Tmax is a Categorical Variable Knowledge Base Why Cmax is a Continuous Variable and Tmax is a Categorical Variable The maximum observed concentration (Cmax) and the time of Cmax (tmax) are both obtained directly…Nathan Teuscher2013 年 2 月 11 日
What is Quantification Anyway? 知识库 What is Quantification Anyway? Bioanalytical analysis is a fundamental tool for the pharmacokineticist. The results of a bioanalysis are…Nathan Teuscher2013 年 2 月 5 日