A Mechanistic Framework for In Vitro-In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug-drug Interaction Between Rosuvastatin and Cyclosporine Publication A Mechanistic Framework for In Vitro-In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug-drug Interaction Between Rosuvastatin and Cyclosporine The interplay between liver metabolizing enzymes and transporters is a complex process involving system-related parameters such as liver blood perfusion…Danielle Pillsbury2013 年 7 月 24 日
A Randomised Study of the Effect of Danoprevir/Ritonavir or Ritonavir on Substrates of Cytochrome P450 (CYP) 3A and 2C9 in Chronic Hepatitis C Patients Using a Drug Cocktail Publication A Randomised Study of the Effect of Danoprevir/Ritonavir or Ritonavir on Substrates of Cytochrome P450 (CYP) 3A and 2C9 in Chronic Hepatitis C Patients Using a Drug Cocktail Danielle Pillsbury2013 年 7 月 20 日
Model-based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development Publication Model-based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development The pharmaceutical industry continues to face significant challenges. Very few compounds that enter development reach…Danielle Pillsbury2013 年 7 月 1 日
Intravenous Topiramate: Safety and Pharmacokinetics Following a Single Dose in Patients with Epilepsy or Migraines Taking Oral Topiramate Publication Intravenous Topiramate: Safety and Pharmacokinetics Following a Single Dose in Patients with Epilepsy or Migraines Taking Oral Topiramate Although topiramate is widely prescribed for epilepsy and migraine, there is no intravenous product. We…Danielle Pillsbury2013 年 6 月 1 日
Intravenous Topiramate: Comparison of Pharmacokinetics and Safety with the Oral Formulation in Healthy Volunteers Publication Intravenous Topiramate: Comparison of Pharmacokinetics and Safety with the Oral Formulation in Healthy Volunteers Although oral topiramate (TPM) products are widely prescribed for migraines and epilepsy, injectable TPM is not available…Danielle Pillsbury2013 年 6 月 1 日
Characterizing Systemic Exposure of Inhaled Drugs: Application to the Long-acting β2-agonist PF-00610355 Publication Characterizing Systemic Exposure of Inhaled Drugs: Application to the Long-acting β2-agonist PF-00610355 PF-00610355 is an orally inhaled long-acting β2-adrenoreceptor agonist that is being developed for the once-daily…Danielle Pillsbury2013 年 6 月 1 日
Brain Extracellular γ-hydroxybutyrate Concentrations are Decreased by L-lactate in Rats: Role in the Treatment of Overdoses Publication Brain Extracellular γ-hydroxybutyrate Concentrations are Decreased by L-lactate in Rats: Role in the Treatment of Overdoses L-lactate represents a potential treatment for GHB overdose by inhibiting GHB renal reabsorption mediated by…Danielle Pillsbury2013 年 5 月 1 日
Model-based Drug Development in Oncology: What’s Next? 刊物 Model-based Drug Development in Oncology: What’s Next? Model-based estimates of tumor growth inhibition (TGI) metrics have the potential to enhance learning in…Danielle Pillsbury2013 年 4 月 1 日
Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide Publication Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide CS-8635, a fixed-dose triple combination of olmesartan, amlodipine, and hydrochlorothiazide, was developed to address the…Danielle Pillsbury2013 年 4 月 1 日
Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body BlogKnowledge Base Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body When I first began learning about pharmacokinetics, I was often confused by the mean residence…Certara2013 年 3 月 28 日