Adding a Placebo Component to Your PK/PD Model in Phoenix
PK/PD modeling is an exciting are of research in clinical pharmacology. Most often we try…
Certara2014 年 8 月 20 日
Bioanalytical Calibration Curves
At the request of a reader, I have decided to extend my series on bioanalysis…
Certara2014 年 8 月 12 日
Assessment of Tumor Growth Inhibition Metrics to Predict Overall Survival
Modeling and simulation is proposed to support drug development phase transitions in oncology. Longitudinal tumor-size…
Certara2014 年 8 月 1 日
Radiometric Analysis
One of the oldest methods used for the quantitation of drug molecules is radiometric analysis.…
Certara2014 年 7 月 29 日
Understanding LC/MS/MS
The most common bioanalytical method in use today is LC/MS/MS, or liquid chromatography (LC) tandem…
Certara2014 年 7 月 15 日
Population Pharmacokinetic Analysis of Dutogliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor
Dutogliptin is a selective dipeptidyl peptidase-4 inhibitor shown to be efficacious and safe in patients…
Certara2014 年 7 月 14 日
Application of a Physiologically-based Pharmacokinetic Model to Predict OATP1B1-related Variability in Pharmacodynamics of Rosuvastatin
Typically, pharmacokinetic-pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability in…
Certara2014 年 7 月 9 日
What is HPLC/UV?
In my series about bioanalysis for the pharmacokineticist, I thought I would start with the…
Certara2014 年 7 月 8 日
Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients
Objectives of this study were to develop a population pharmacokinetic (PopPK) model for tacrolimus in…
Certara2014 年 6 月 1 日
