Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 Publication Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 RG7652 is a fully humanized monoclonal antibody targeting human PCSK9, a regulator of serum low…Certara2015 年 3 月 31 日
Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Avibactam Alone and in Combination with Ceftazidime in Healthy Male Volunteers: Results of Two Randomized, Placebo-controlled Studies Publication Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Avibactam Alone and in Combination with Ceftazidime in Healthy Male Volunteers: Results of Two Randomized, Placebo-controlled Studies Avibactam is a novel non-β-lactam β-lactamase inhibitor effective against Ambler class A, C and some…Certara2015 年 3 月 27 日
Pharmacokinetics and Safety of Oseltamivir in Patients with End-stage Renal Disease Treated with Automated Peritoneal Dialysis Publication Pharmacokinetics and Safety of Oseltamivir in Patients with End-stage Renal Disease Treated with Automated Peritoneal Dialysis Certara2015 年 3 月 25 日
Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison Between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys Publication Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison Between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on…Certara2015 年 2 月 15 日
Calculating the Elimination Rate Constant BlogKnowledge Base Calculating the Elimination Rate Constant The elimination rate constant is the rate at which drug is cleared from the body…Certara2015 年 2 月 2 日
Population Pharmacokinetics of Ceftolozane/Tazobactam in Healthy Volunteers, Subjects with Varying Degrees of Renal Function and Patients with Bacterial Infections Publication Population Pharmacokinetics of Ceftolozane/Tazobactam in Healthy Volunteers, Subjects with Varying Degrees of Renal Function and Patients with Bacterial Infections Ceftolozane/tazobactam is a novel antipseudomonal cephalosporin and a β-lactamase inhibitor in clinical development for treatment…Certara2015 年 2 月 1 日
Common Misconceptions About Computer System Validation Blog 关于计算机系统验证的常见误解 Drug development professionals frequently use computer systems to help them understand the pharmacokinetics (PK) and…Certara2015 年 1 月 28 日
Using Modeling and Simulation to Quantify the PK of an Anti-HIV Drug for Babies Blog Using Modeling and Simulation to Quantify the PK of an Anti-HIV Drug for Babies As a scientist at Certara and proud Dad to my three kids, pediatric drug development…Certara2015 年 1 月 15 日
The Effect of Plasmapheresis on Blood Pressure in Voluntary Plasma Donors Publication The Effect of Plasmapheresis on Blood Pressure in Voluntary Plasma Donors Donor plasmapheresis involves the removal of a weight-adjusted volume of plasma and the return of…Certara2015 年 1 月 1 日
Population Dose-response Analysis of Daily Seizure Count Following Vigabatrin Therapy in Adult and Pediatric Patients with Refractory Complex Partial Seizures Publication Population Dose-response Analysis of Daily Seizure Count Following Vigabatrin Therapy in Adult and Pediatric Patients with Refractory Complex Partial Seizures Vigabatrin is an irreversible inhibitor of γ-aminobutyric acid transaminase (GABA-T) and is used as an…Certara2015 年 1 月 1 日