Modeling and Simulation - PK/PD Archives | 第 18 页，共 37 页

Publication

Modeling & Simulation Relating Survival to Tumor Growth Inhibition in Patients

The published OS model and resultant simulations can be leveraged to support Phase II design…

Danielle Pillsbury2015 年 9 月 1 日

Knowledge Base

Derivation for Logarithmic Trapezoidal AUC Calculation

Calculating area under the curve requires the use of two separate equations: one is follows…

Nathan Teuscher2015 年 8 月 5 日

Publication

Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium Tuberculosis

Danielle Pillsbury2015 年 7 月 23 日

Publication

Population Pharmacokinetic Modeling of Motesanib and Its Active Metabolite, M4, in Cancer Patients

Motesanib is a small molecule and potent multikinase inhibitor with antiangiogenic and antitumor activity. Population…

Danielle Pillsbury2015 年 7 月 23 日

Publication

Population Pharmacokinetic Analysis of Thrombomodulin Alfa to Support Dosing Rationale in Patients with Renal Impairment

Thrombomodulin alfa is a soluble recombinant human thrombomodulin that was reported to enhance the reversal…

Danielle Pillsbury2015 年 5 月 1 日

Publication

Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis

Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than…

Danielle Pillsbury2015 年 5 月 1 日

Blog

儿科用药剂量：小患者，大挑战

儿科药物开发的挑战与复杂性已广为人知。Pharmacometric modeling and simulation (M&S)…

Certara2015 年 4 月 23 日

Publication

Effect of Age and Sex on the Pharmacokinetics and Safety of Avibactam in Healthy Volunteers

Avibactam is a novel non-β-lactam β-lactamase inhibitor currently being assessed in combination with ceftazidime, ceftaroline…

Danielle Pillsbury2015 年 4 月 1 日

Publication

Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9

RG7652 is a fully humanized monoclonal antibody targeting human PCSK9, a regulator of serum low…

Danielle Pillsbury2015 年 3 月 31 日

Publication

Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Avibactam Alone and in Combination with Ceftazidime in Healthy Male Volunteers: Results of Two Randomized, Placebo-controlled Studies

Avibactam is a novel non-β-lactam β-lactamase inhibitor effective against Ambler class A, C and some…

Danielle Pillsbury2015 年 3 月 27 日

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Modeling and Simulation – PK/PD

Modeling & Simulation Relating Survival to Tumor Growth Inhibition in Patients

Derivation for Logarithmic Trapezoidal AUC Calculation

Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium Tuberculosis

Population Pharmacokinetic Modeling of Motesanib and Its Active Metabolite, M4, in Cancer Patients

Population Pharmacokinetic Analysis of Thrombomodulin Alfa to Support Dosing Rationale in Patients with Renal Impairment

Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis

儿科用药剂量：小患者，大挑战

Effect of Age and Sex on the Pharmacokinetics and Safety of Avibactam in Healthy Volunteers

Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9

Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Avibactam Alone and in Combination with Ceftazidime in Healthy Male Volunteers: Results of Two Randomized, Placebo-controlled Studies

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