Immune Cell-based Screening Assay for Response to Anticancer Agents: Applications in Pharmacogenomics Publication Immune Cell-based Screening Assay for Response to Anticancer Agents: Applications in Pharmacogenomics Certara2016 年 2 月 26 日
How Modeling and Simulation Can Bring New Immuno-oncology Treatments to Patients Blog 建模与模拟如何为患者带来新型的免疫肿瘤疗法 Immuno-oncology, which harnesses the patient's own immune system to fight cancer, is one of the…Certara2016 年 2 月 16 日
Conventional & Mechanistic IVIVC: Complementary or Clashing Methods? 博客 Conventional & Mechanistic IVIVC: Complementary or Clashing Methods? An IVIVC (in vitro-in vivo correlation) is a mathematical relationship that predicts key pharmacokinetic parameters…Certara2016 年 2 月 9 日
Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases Publication Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases Certara2016 年 2 月 1 日
Short Communication Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are Associated with p16 INK4a Expression in Subjects on Combination Therapy Publication Short Communication Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are Associated with p16 INK4a Expression in Subjects on Combination Therapy Certara2016 年 1 月 5 日
Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis Publication Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis Mastitis is a frequent problem among dairy cows, reducing milk yield and increasing cull rates.…Certara2016 年 1 月 1 日
Back to the Future (of Pharmacometrics) with Dr. Lawrence Lesko Blog Back to the Future (of Pharmacometrics) with Dr. Lawrence Lesko Pharmacometrics uses mathematical models of biology, pharmacology, disease, and physiology to describe and quantify interactions…Certara2015 年 12 月 1 日
9 Frequently Misunderstood Concepts in PK/PD Modeling Knowledge Base 9 Frequently Misunderstood Concepts in PK/PD Modeling In teaching pharmacometrics, I've noticed that scientists have difficulty with certain PK/PD modeling concepts. Maybe…Certara2015 年 11 月 3 日
Population PK & Dosing Implications for Cobimetinib in Cancer Patients Publication Population PK & Dosing Implications for Cobimetinib in Cancer Patients A population pharmacokinetic model was developed for cobimetinib in cancer patients. Covariates had minimal impact…Certara2015 年 11 月 1 日
Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model Publication Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model Bioavailability of orally administered drugs can be influenced by a number of factors including release…Certara2015 年 11 月 1 日