Pediatrics Archives

Publication

Prediction of Voriconazole Non-linear Pharmacokinetics Using a Pediatric Physiologically-based Pharmacokinetic Modeling Approach

We read with interest the report by Zane and Thakker entitled ‘‘A PBPK model for…

webdev2015 年 5 月 1 日

Blog

儿科用药剂量：小患者，大挑战

儿科药物开发的挑战与复杂性已广为人知。Pharmacometric modeling and simulation (M&S)…

Nastya Kassir2015 年 4 月 23 日

Publication

Vigabatrin Pediatric Dosing Information for Refractory Complex Partial Seizures: Results from a Population Dose-response Analysis

We predicted vigabatrin dosages for adjunctive therapy for pediatric patients with refractory complex partial seizures…

webdev2014 年 12 月 1 日

Publication

Meropenem in Children Receiving Continuous Renal Replacement Therapy: Clinical Trial Simulations Using Realistic Covariates

Meropenem is frequently prescribed in children receiving continuous renal replacement therapy (CRRT). Fluid overload is…

webdev2014 年 12 月 1 日

Publication

Population Pharmacokinetics Analysis of Vigabatrin in Adults and Children with Epilepsy and Children with Infantile Spasms

Vigabatrin is an inhibitor of γ-aminobutyric acid transaminase. The purpose of these analyses was to…

webdev2014 年 11 月 1 日

Publication

Development of Physiologically-based Pharmacokinetic Model to Evaluate the Relative Systemic Exposure to Quetiapine After Administration of IR and XR Formulations to Adults, Children, and Adolescents

Quetiapine is an atypical antipsychotic drug with a high permeability, moderate solubility and defined as…

webdev2014 年 9 月 1 日

Publication

A Re-evaluation and Validation of Ontogeny Functions for CYPs 1A2 and 3A4 Based on In Vivo Data

Current cytochrome P450 (CYP) 1A2 and 3A4 ontogeny profiles, which are derived mainly from in…

webdev2014 年 7 月 1 日

Publication

Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients

Objectives of this study were to develop a population pharmacokinetic (PopPK) model for tacrolimus in…

webdev2014 年 6 月 1 日

Publication

Conversion from Twice- to Once-daily Tacrolimus in Pediatric Kidney Recipients: A Pharmacokinetic and Bioequivalence Study

The objectives of this study were to investigate pharmacokinetic and pharmacogenetic parameters during the conversion…

webdev2014 年 6 月 1 日

Publication

The Posology of Oseltamivir in Infants with Influenza Infection Using a Population Pharmacokinetic Approach

webdev2014 年 5 月 27 日

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儿科

Prediction of Voriconazole Non-linear Pharmacokinetics Using a Pediatric Physiologically-based Pharmacokinetic Modeling Approach

儿科用药剂量：小患者，大挑战

Vigabatrin Pediatric Dosing Information for Refractory Complex Partial Seizures: Results from a Population Dose-response Analysis

Meropenem in Children Receiving Continuous Renal Replacement Therapy: Clinical Trial Simulations Using Realistic Covariates

Population Pharmacokinetics Analysis of Vigabatrin in Adults and Children with Epilepsy and Children with Infantile Spasms

Development of Physiologically-based Pharmacokinetic Model to Evaluate the Relative Systemic Exposure to Quetiapine After Administration of IR and XR Formulations to Adults, Children, and Adolescents

A Re-evaluation and Validation of Ontogeny Functions for CYPs 1A2 and 3A4 Based on In Vivo Data

Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients

Conversion from Twice- to Once-daily Tacrolimus in Pediatric Kidney Recipients: A Pharmacokinetic and Bioequivalence Study

The Posology of Oseltamivir in Infants with Influenza Infection Using a Population Pharmacokinetic Approach

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