Model Informed Drug Development Archives

Publication

Covariation of Human Microsomal Protein per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling

Scaling of metabolic clearance values from liver microsomal data or recombinantly expressed cytochrome P450 enzymes…

Certara2008 年 12 月 1 日

Publication

Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential

AIMS: To characterize the cytochrome P450 enzyme(s) responsible for the N-dealkylation of maraviroc in vitro,…

Certara2008 年 10 月 1 日

Publication

Integrating Systems Approaches into Pharmaceutical Sciences

During the first week of December 2007, the European Federation for Pharmaceutical Sciences (EUFEPS) and…

Certara2008 年 9 月 2 日

Publication

Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability

This is a summary report of the EUFEPS & COST B25 conference on Bioavailability and…

Certara2008 年 8 月 1 日

Publication

Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain

The aim of this study was to develop a pain relief model for a cyclooxygenase…

Certara2008 年 7 月 1 日

Publication

In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and Their Utility for Predicting Drug-drug Interactions

It is widely accepted that today's practice of polypharmacy inevitably increases the incidence of drug-drug…

Certara2008 年 6 月 1 日

Publication

Integrated In Vitro Analysis for the In Vivo Prediction of Cytochrome P450-mediated Drug-drug Interactions

Unbound IC50 (IC50,u) values of 15 drugs were determined in eight recombinantly expressed human cytochromes P450…

Certara2008 年 6 月 1 日

Publication

Application of CYP3A4 In Vitro Data to Predict Clinical Drug-drug Interactions: Predictions of Compounds as Objects of Interaction

Numerous retrospective analyses have shown the utility of in vitro systems for predicting potential drug-drug interactions (DDIs). Prediction of DDIs…

Certara2008 年 5 月 1 日

Publication

Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions

Three approaches were compared to predict the actual magnitude of drug interaction (the mean fold-change in the area under…

Certara2007 年 10 月 1 日

Publication

Prediction of Intestinal First-pass Drug Metabolism

Despite a lower content of many drug metabolising enzymes in the intestinal epithelium compared to…

Certara2007 年 10 月 1 日

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模型引导的药物开发

Covariation of Human Microsomal Protein per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling

Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential

Integrating Systems Approaches into Pharmaceutical Sciences

Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability

Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain

In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and Their Utility for Predicting Drug-drug Interactions

Integrated In Vitro Analysis for the In Vivo Prediction of Cytochrome P450-mediated Drug-drug Interactions

Application of CYP3A4 In Vitro Data to Predict Clinical Drug-drug Interactions: Predictions of Compounds as Objects of Interaction

Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions

Prediction of Intestinal First-pass Drug Metabolism

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