Prediction of Intestinal First-pass Drug Metabolism
Despite a lower content of many drug metabolising enzymes in the intestinal epithelium compared to…
Certara2007 年 10 月 1 日
Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes
An analysis of reported hepatic abundances of CYP3A4 and 3A5 indicated that values determined by…
Certara2007 年 10 月 1 日
A Systematic Comparison of Software Dedicated to Meta-analysis of Causal Studies
Our objective was to systematically assess the differences in features, results, and usability of currently…
Certara2007 年 9 月 10 日
Modeling, Simulation, and the Critical Path
The benefits of modeling and simulation fall into two categories: Increased certainty in trial designs…
Certara2007 年 9 月 6 日
Theoretical Assessment of a New Experimental Protocol for Determining Kinetic Values Describing Mechanism (time)-based Enzyme Inhibition
We have shown previously that the conventional experimental protocol (CEP) used to characterise mechanism-based enzyme…
Certara2007 年 7 月 1 日
The Use of Mechanistic DM-PK-PD Modeling to Assess the Power of Pharmacogenetic Studies—CYP2C9 and Warfarin as an Example
The aim of this study was to assess the power of in vivo studies needed…
Certara2007 年 7 月 1 日
Kinetics of the Time-dependent Inactivation of CYP2D6 in Cryopreserved Human Hepatocytes by Methylenedioxymethamphetamine (MDMA)
Methylenedioxymethamphetamine (MDMA) was investigated in cryopreserved human hepatocytes as a time-dependent inactivator (TDI) of CYP2D6…
Certara2007 年 5 月 1 日
Predictive Population Pharmacokinetic/Pharmacodynamic Model for a Novel COX-2 Inhibitor
The objectives of these analyses were to (1) develop a population pharmacokinetic/pharmacodynamic model for a…
Certara2007 年 3 月 1 日
Misuse of the Well-stirred Model of Hepatic Drug Clearance
The “well-stirred” model of hepatic drug clearance was first proposed by Gillette and established by…
Certara2007 年 3 月 1 日
Time-dependent CYP Inhibition
Time-dependent inhibition (TDI) of CYP refers to a change in potency during an in vitro incubation or dosing period…
Certara2007 年 2 月 1 日
