Prediction of In Vivo Drug Clearance from In Vitro Data, I: Impact of Inter-individual Variability Publication Prediction of In Vivo Drug Clearance from In Vitro Data, I: Impact of Inter-individual Variability The Simcyp® Population-Based ADME Simulator was used to predict median drug clearances and their associated…Danielle Pillsbury2006 年 6 月 1 日
Prediction of In Vivo Drug Clearance from In Vitro Data, II: Potential Inter-ethnic Differences Publication Prediction of In Vivo Drug Clearance from In Vitro Data, II: Potential Inter-ethnic Differences Potential differences in drug clearance between Japanese and Caucasians were investigated by integrating data on…Danielle Pillsbury2006 年 6 月 1 日
Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor Publication Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor A predictive population pharmacokinetic model was developed for a novel cyclooxygenase-2 (COX-2) inhibitor CS-706, using…Danielle Pillsbury2006 年 5 月 1 日
Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation Publication Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation The aim of this study was to develop a pain relief model for a cyclooxygenase…Danielle Pillsbury2006 年 4 月 1 日
Kinetic Values for Mechanism-based Enzyme Inhibition: Assessing the Bias Introduced by the Conventional Experimental Protocol Publication Kinetic Values for Mechanism-based Enzyme Inhibition: Assessing the Bias Introduced by the Conventional Experimental Protocol The in vitro characterisation of a mechanism-based enzyme inactivator (MBEI) includes determination of the maximum…Danielle Pillsbury2005 年 11 月 1 日
Model-based Development of Gemcabene, a New Lipid-altering Agent Publication Model-based Development of Gemcabene, a New Lipid-altering Agent The purpose of this study was to evaluate the value of model-based, quantitative decision making…Danielle Pillsbury2005 年 10 月 7 日
Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model Publication Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model Ciclesonide is a novel and effective inhaled corticosteroid for the treatment of asthma that is…Danielle Pillsbury2005 年 9 月 1 日
Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation Publication Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation A novel model-based meta-analysis was used to quantify the dose-response relationship of sumatriptan and eletriptan…Danielle Pillsbury2005 年 9 月 1 日
Modelling Approaches to Dose Estimation in Children Publication Modelling Approaches to Dose Estimation in Children Most of the drugs on the market are originally developed for adults and dosage selection…Danielle Pillsbury2005 年 6 月 1 日
Techniques: Application of Systems Biology to Absorption, Distribution, Metabolism, Excretion, and Toxicity Publication Techniques: Application of Systems Biology to Absorption, Distribution, Metabolism, Excretion, and Toxicity It is widely recognized that either predicting or determining the absorption, distribution, metabolism, excretion and…Danielle Pillsbury2005 年 4 月 1 日