Pharmacokinetic mAb-mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts Publication Pharmacokinetic mAb-mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts To date, there has been little investigation of the risk for drug-drug interactions involving monoclonal…Certara2012 年 9 月 1 日
Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis Publication Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis Lesion count observed on brain magnetic resonance imaging scan is a common end point in…Certara2012 年 9 月 1 日
Dose Correction for the Michaelis-Menten Approximation of the Target—Mediated Drug Disposition Model Publication Dose Correction for the Michaelis-Menten Approximation of the Target—Mediated Drug Disposition Model The Michaelis-Menten (M-M) approximation of the target-mediated drug disposition (TMDD) pharmacokinetic (PK) model was derived…Certara2012 年 8 月 23 日
The Right Compound in the Right Assay at the Right Time: An Integrated Discovery DMPK Strategy Publication The Right Compound in the Right Assay at the Right Time: An Integrated Discovery DMPK Strategy The high rate of attrition during drug development and its associated high research and development…Certara2012 年 8 月 1 日
Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-induced Inflammation in Rats Publication Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-induced Inflammation in Rats Increased expression of inducible nitric oxide synthase (iNOS) resulting in nitric oxide elevation represents an…Certara2012 年 8 月 1 日
γ-hydroxybutyrate (GHB)-induced Respiratory Depression: Combined Receptor-transporter Inhibition Therapy for Treatment in GHB Overdose Publication γ-hydroxybutyrate (GHB)-induced Respiratory Depression: Combined Receptor-transporter Inhibition Therapy for Treatment in GHB Overdose Overdose of & γ;-hydroxybutyrate (GHB) frequently causes respiratory depression, occasionally resulting in death; however, little…Certara2012 年 8 月 1 日
Population Pharmacokinetics of Vernakalant Hydrochloride Injection (RSD1235) in Patients with Atrial Fibrillation or Atrial Flutter Publication Population Pharmacokinetics of Vernakalant Hydrochloride Injection (RSD1235) in Patients with Atrial Fibrillation or Atrial Flutter Vernakalant hydrochloride is a novel, predominantly atrial-selective antiarrhythmic drug that effectively and rapidly terminates atrial…Certara2012 年 7 月 1 日
Sex Differences in the Clearance of CYP3A4 Substrates: Exploring Possible Reasons for the Substrate Dependency and Lack of Consensus Publication Sex Differences in the Clearance of CYP3A4 Substrates: Exploring Possible Reasons for the Substrate Dependency and Lack of Consensus Sex differences in the clearance of substrates of Cytochrome P4503A (CYP3A4) have been reported frequently…Certara2012 年 7 月 1 日
Prediction of Concentration-time Profile and Its Inter-individual Variability Following the Dermal Drug Absorption Publication Prediction of Concentration-time Profile and Its Inter-individual Variability Following the Dermal Drug Absorption Estimation of systemic exposure after absorption of any xenobiotic from the skin is very important…Certara2012 年 7 月 1 日
Physiologically-based Pharmacokinetics Joined with In Vitro-In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology Publication Physiologically-based Pharmacokinetics Joined with In Vitro-In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology Classic pharmacokinetics (PK) rarely takes into account the full knowledge of physiology and biology of…Certara2012 年 7 月 1 日