A Physiologically-based Pharmacokinetic (PBPK) Approach to Evaluate Pharmacokinetics in Patients with Cancer Publication A Physiologically-based Pharmacokinetic (PBPK) Approach to Evaluate Pharmacokinetics in Patients with Cancer Potential differences in pharmacokinetics (PK) between healthy subjects and patients with cancer were investigated using…Certara2013 年 4 月 1 日
Effects of Monocarboxylate Transporter Inhibition on the Oral Toxicokinetics/Toxicodynamics of γ-hydroxybutyrate and γ-butyrolactone Publication Effects of Monocarboxylate Transporter Inhibition on the Oral Toxicokinetics/Toxicodynamics of γ-hydroxybutyrate and γ-butyrolactone Respiratory depression and death secondary to respiratory arrest have occurred after oral overdoses of γ-hydroxybutyrate…Certara2013 年 4 月 1 日
Model-based Drug Development in Oncology: What’s Next? 刊物 Model-based Drug Development in Oncology: What’s Next? Model-based estimates of tumor growth inhibition (TGI) metrics have the potential to enhance learning in…Certara2013 年 4 月 1 日
Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide Publication Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide CS-8635, a fixed-dose triple combination of olmesartan, amlodipine, and hydrochlorothiazide, was developed to address the…Certara2013 年 4 月 1 日
Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis Publication Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis Axitinib is a potent and selective inhibitor of vascular endothelial growth factor receptors 1, 2,…Certara2013 年 3 月 28 日
A Poor Metabolizer of Both CYP2C19 and CYP2D6 Identified by Mechanistic Pharmacokinetic Simulation in a Fatal Drug Poisoning Case Involving Venlafaxine Publication A Poor Metabolizer of Both CYP2C19 and CYP2D6 Identified by Mechanistic Pharmacokinetic Simulation in a Fatal Drug Poisoning Case Involving Venlafaxine We present a fatal drug poisoning case involving venlafaxine (VEN). The deceased took his medication…Certara2013 年 3 月 10 日
Race and Drug Formulation Influence on Mycophenolic Acid Pharmacokinetics in Stable Renal Transplant Recipients Publication Race and Drug Formulation Influence on Mycophenolic Acid Pharmacokinetics in Stable Renal Transplant Recipients Limited mycophenolic acid (MPA) data are available comparing racial influence on mycophenolate mofetil (MMF) and…Certara2013 年 3 月 1 日
In Vitro to Human In Vivo Translation—Pharmacokinetics and Pharmacodynamics of Quinidine Publication In Vitro to Human In Vivo Translation—Pharmacokinetics and Pharmacodynamics of Quinidine The translational sciences aim to transfer results from basic research to the treatment of animals…Certara2013 年 3 月 1 日
Application of Knockout Mouse Models to Investigate the Influence of FcγR on the Pharmacokinetics and Anti-platelet Effects of MWReg30, a Monoclonal Anti-GPIIb Antibody Publication Application of Knockout Mouse Models to Investigate the Influence of FcγR on the Pharmacokinetics and Anti-platelet Effects of MWReg30, a Monoclonal Anti-GPIIb Antibody This work evaluates the influence of FcγR on the pharmacokinetics and pharmacodynamics of a rat…Certara2013 年 2 月 28 日
Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology Publication Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology The nerve growth factor (NGF) pathway is of great interest as a potential source of…Certara2013 年 2 月 21 日