Differences in Cytochrome P450-mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically-based Pharmacokinetic Modeling Publication Differences in Cytochrome P450-mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically-based Pharmacokinetic Modeling International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH)…Certara2013 年 12 月 1 日
Absence of Pharmacokinetic Drug-drug Interaction of Pertuzumab with Trastuzumab and Docetaxel Publication Absence of Pharmacokinetic Drug-drug Interaction of Pertuzumab with Trastuzumab and Docetaxel Pertuzumab is a novel antihuman epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody. Combined…Certara2013 年 11 月 24 日
Phoenix WinNonlin: A State of the Art Software Tool for Pre-clinical PK and TK Analysis On-Demand Webinar Phoenix WinNonlin: A State of the Art Software Tool for Pre-clinical PK and TK Analysis Are you currently using Excel for PK/TK analysis? Phoenix WinNonlin streamlines analyses and generates all…Certara2013 年 11 月 21 日
Introduction to Population PK/PD Analysis Using Phoenix NLME On-Demand Webinar Introduction to Population PK/PD Analysis Using Phoenix NLME Phoenix NLME provides sophisticated algorithms and powerful and flexible data processing and modeling tools for…Certara2013 年 11 月 14 日
Predicted Heart Rate Effect of Inhaled LABA PF-00610355 in Volunteers and COPD Patients Publication Predicted Heart Rate Effect of Inhaled LABA PF-00610355 in Volunteers and COPD Patients The aim of this study was to assess the cardiovascular effects of a new inhaled…Certara2013 年 11 月 1 日
Prediction of Overall Survival or Progression Free Survival by Disease Control Rate at Week 8 Is Independent of Ethnicity: Western Versus Chinese Patients with First-line Non-small Cell Lung Cancer Treated with Chemotherapy with or without Bevacizumab Publication Prediction of Overall Survival or Progression Free Survival by Disease Control Rate at Week 8 Is Independent of Ethnicity: Western Versus Chinese Patients with First-line Non-small Cell Lung Cancer Treated with Chemotherapy with or without Bevacizumab Categorizations of best response observed at week 8 of first-line treatment in two studies of…Certara2013 年 10 月 22 日
Inter-individual Variability in Levels of Human Microsomal Protein and Hepatocellularity per Gram of Liver Publication Inter-individual Variability in Levels of Human Microsomal Protein and Hepatocellularity per Gram of Liver This study sought to determine levels of microsomal protein (MPPGL) and hepatocellularity (HPGL) per gram…Certara2013 年 10 月 1 日
Differential Pharmacokinetics of Ganitumab in Patients with Metastatic Pancreatic Cancer Versus Other Advanced Solid Cancers Publication Differential Pharmacokinetics of Ganitumab in Patients with Metastatic Pancreatic Cancer Versus Other Advanced Solid Cancers Ganitumab is an investigational, fully human monoclonal antibody antagonist of the insulin-like growth factor-1 receptor…Certara2013 年 10 月 1 日
Exposure-response Analysis of Pertuzumab in HER2-positive Metastatic Breast Cancer: Absence of Effect on QTc Prolongation and Other ECG Parameters Publication Exposure-response Analysis of Pertuzumab in HER2-positive Metastatic Breast Cancer: Absence of Effect on QTc Prolongation and Other ECG Parameters The phase III trial of pertuzumab plus trastuzumab plus docetaxel versus placebo plus trastuzumab plus…Certara2013 年 9 月 3 日
Toxicokinetics/Toxicodynamics of γ-hydroxybutyrate-ethanol Intoxication: Evaluation of Potential Treatment Strategies Publication Toxicokinetics/Toxicodynamics of γ-hydroxybutyrate-ethanol Intoxication: Evaluation of Potential Treatment Strategies γ-Hydroxybutyrate (GHB), a common drug of abuse, is often coingested with ethanol. Increasing renal clearance…Certara2013 年 9 月 1 日