Development of a human PBMC TXG-MAPr as a mechanistic framework to interpret toxicodynamic variability across the human population Poster 开发人外周血单核细胞(PBMC)TXG-MAPr 模型,作为解释人类群体中毒理动力学变异性的机制框架 Leiden University and EFSA researchers present the PBMC TXG-MAPr — a network-based transcriptomic tool mapping…Certara2026 年 6 月 23 日
Characterization of human toxicodynamic variability using peripheral blood mononuclear cells from a large cohort of healthy volunteers Poster 利用来自大型健康志愿者队列的外周血单核细胞,对人类毒理动力学变异性进行特征分析 Research from Leiden University and EFSA characterizing interindividual toxicodynamic variability using peripheral blood mononuclear cells…Certara2026 年 6 月 23 日
Certara Launches Bio Venture Catalyst for Emerging Biotechs to De-risk Investment and Accelerate Development Announcement Certara 推出“Bio Venture Catalyst”计划,助力新兴生物科技企业降低投资风险并加速研发进程 Integrated offering combines drug development, regulatory, commercial, and investor strategy expertise to help early-stage biotech…Danielle Pillsbury2026 年 6 月 23 日
Integrating Endogenous Ligand Competition into a Mechanistic Whole-Body PBPK Model of Therapeutic Monoclonal Antibodies Poster 将内源性配体竞争纳入治疗性单克隆抗体的机制全身 PBPK 模型 Discover how endogenous ligand competition was incorporated into a whole-body PBPK model to improve prediction…Certara2026 年 6 月 23 日
Application of IO Simulator in Immuno-Oncology Combination Therapy: A Small Cell Lung Cancer Case Study Poster Application of IO Simulator in Immuno-Oncology Combination Therapy: A Small Cell Lung Cancer Case Study Learn how Certara's IO Simulator was used to predict efficacy, cytokine release syndrome risk, and…Certara2026 年 6 月 23 日
Mechanistic Modelling of CRS in T-cell Engagers – An Application for Blinatumomab Poster Mechanistic Modelling of CRS in T-cell Engagers – An Application for Blinatumomab Discover how Quantitative Systems Pharmacology (QSP) was used to predict cytokine release syndrome risk and…Certara2026 年 6 月 23 日
Machine Learning-Based Covariate Selection for Population Pharmacokinetic Modeling Poster Machine Learning-Based Covariate Selection for Population Pharmacokinetic Modeling Authors: Ibtissem Rebai (Certara), Stephen Duffull (Certara), Ayman Akil (Certara), Anna Largajolli (Certara), Floris Fauchet…Certara2026 年 6 月 22 日
Shaping the future of AI/ML in pharmacometrics through collaboration, education and best practices Poster Shaping the future of AI/ML in pharmacometrics through collaboration, education and best practices Discover how the AI/ML Special Interest Group is advancing responsible artificial intelligence in pharmacometrics through…Certara2026 年 6 月 22 日
Accelerating QSP Virtual Population Generation Through Active Learning and Bayesian Optimization Poster Accelerating QSP Virtual Population Generation Through Active Learning and Bayesian Optimization Discover how active learning and Bayesian optimization improve virtual population generation for quantitative systems pharmacology…Certara2026 年 6 月 18 日
Mechanistic QSP Modeling to Support KIT Inhibitor Dose Selection, Biomarker Strategy, and Clinical Development Poster Mechanistic QSP Modeling to Support KIT Inhibitor Dose Selection, Biomarker Strategy, and Clinical Development Discover how a mechanistic quantitative systems pharmacology (QSP) model predicts mast cell inhibition and depletion…Certara2026 年 6 月 16 日